Crimean-Congo hemorrhagic fever virus genome L RNA segment and encoded protein
Crimean-Congo hemorrhagic fever virus genome L RNA segment and encoded protein
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DOI：
10.1016/j.virol.2003.09.042
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发表时间：
2004-03-30
期刊：
影响因子：
3.7
通讯作者：
Nichol, ST
中科院分区：
文献类型：
--
作者：
Honig, JE;Osborne, JC;Nichol, ST
克里米亚-刚果出血热（CCHF）病毒（Nairovirus属，布尼亚病毒科）的L RNA基因组片段和预测编码的L聚合酶蛋白的序列分析表明，它们的大小约为其他布尼亚病毒属病毒的两倍。CCHF病毒L片段和编码的蛋白质（分别为12164个核苷酸和3944个氨基酸）在大小和序列上与内罗病毒Dugbe病毒的那些相似（分别为12255/62%和4036/62%核苷酸和氨基酸长度/同一性）。在内罗病毒Dugbe、CCHF和内罗毕绵羊病（NSD）的L蛋白氨基末端鉴定出卵巢肿瘤（OTU）样蛋白酶基序，表明这些蛋白是最近描述的OTU样蛋白酶家族的成员，并表明这些大蛋白可能是自蛋白水解切割或参与去泛素化的多聚蛋白。爱思唯尔公司出版
Sequence analysis of the L RNA genome segment and predicted encoded L polymerase protein of Crimean-Congo hemorrhagic fever (CCHF) virus (genus Nairovirus, family Bunyaviridae) demonstrates that they are approximately twice the size of those found in viruses of other bunyavirus genera. The CCHF virus L segment and encoded protein (12164 nucleotides and 3944 amino acids, respectively) are similar in size and sequence to those of the nairovirus Dugbe virus (12255/62% and 4036/62% nucleotide and amino acid length/identity, respectively). The identification of an ovarian tumor (OTU)-like protease motif in the L protein amino termini of the nairoviruses Dugbe, CCHF, and Nairobi sheep disease (NSD) indicates these proteins are members of the recently described OTU-like protease family and suggests that these large proteins may be polyproteins that are autoproteolytically cleaved or involved in deubiquitination. Published by Elsevier Inc.