Serum Level of Soluble Vascular Cell Adhesion Molecule 1 Is a Valuable Prognostic Marker in Colorectal Carcinoma
Serum Level of Soluble Vascular Cell Adhesion Molecule 1 Is a Valuable Prognostic Marker in Colorectal Carcinoma
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DOI：
10.1007/dcr.0b013e3181a0d144
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发表时间：
2009-07-01
影响因子：
3.9
通讯作者：
Kusunoki, Masato
中科院分区：
文献类型：
--
作者：
Okugawa, Yoshinaga;Miki, Chikao;Kusunoki, Masato
目的：血管细胞粘附分子1在实体瘤的扩大和/或转移中起重要作用。本研究旨在探讨可溶性血管细胞粘附分子1（sVCAM 1）在大肠癌患者血清中的表达及其临床意义，并探讨其在大肠癌局部表达的生物学意义。收集了128名患者的癌组织。采用酶联免疫吸附法检测患者血清和癌组织中可溶性血管细胞粘附分子1的水平。结果：患者血清和癌组织中可溶性血管细胞粘附分子1的平均水平显著高于对照组。血清可溶性血管细胞粘附分子1升高与临床病理参数如肿瘤大小、淋巴结转移、远处转移和不良预后显著相关。考克斯多因素分析显示，远处转移和血清可溶性血管细胞粘附分子1水平升高是预后不良的独立危险因素。可溶性血管细胞粘附分子1阳性的2期患者的预后与3期患者相当。结论：术前可溶性血管细胞粘附分子1水平可反映大肠癌的病情进展，是大肠癌尤其是2期大肠癌的敏感生物标志物。
PURPOSE: Vascular cell adhesion molecule 1 plays an important role in solid tumor enlargement and/or metastasis. This study evaluated the clinical significance of measuring serum levels of soluble vascular cell adhesion molecule 1 in colorectal cancer and aimed to clarify the biologic significance of its local expression.METHODS: Serum was collected from 161 patients with colorectal cancer and 26 healthy volunteers. Cancer tissue was collected from 128 patients. The level of soluble vascular cell adhesion molecule 1 in serum and cancer tissue was measured by enzyme-linked immunosorbent assay.RESULTS: The mean soluble vascular cell adhesion molecule 1 level in patients was significantly higher than that in control subjects. Elevated serum soluble vascular cell adhesion molecule 1 was significantly associated with clinicopathologic parameters such as tumor size, lymph node metastasis, distant metastasis, and poor prognosis. In Cox multivariate analysis, distant metastasis and elevated serum soluble vascular cell adhesion molecule 1 level were independent risk factors predicting poor prognosis. The prognosis for Stage 2 patients positive for soluble vascular cell adhesion molecule 1 was comparable to that for Stage 3 patients. In addition, the serum level of soluble vascular cell adhesion molecule 1 level was correlated negatively with the cancer tissue level.CONCLUSION: The preoperative level of soluble vascular cell adhesion molecule 1 level reflected disease progression and was a sensitive biomarker for colorectal cancer, especially Stage 2 disease.