Removal of biofilm is essential for long-term ventilation tube retention.
Removal of biofilm is essential for long-term ventilation tube retention.
复制标题
去除生物膜对于长期保留通气管至关重要。
DOI：
10.12998/wjcc.v8.i9.1592
复制
发表时间：
2020
影响因子：
1.1
通讯作者：
K. Su
中科院分区：
文献类型：
--
作者：
Q. Ma;Hui Wang;Zheng;Ya;Dongzhen Yu;Pengjun Wang;Hai;K. Su
背景
尽管许多耳部疾病需要长期保留通气管，但在 3 至 12 个月内观察到患者自发拔除传统通气管。为了解决这个问题，我们旨在确定一种长期保留通气管的新方法。
目的
探讨去除生物膜对于长期保留鼓室造口通气管的价值。
方法
采用病例对照研究设计来评估通过直接去除生物膜（通过手术剥脱）对接受鼓膜切开术并放置通气管的患者进行长期留置管的安全性和有效性。将患者随机分为两组：对照组和治疗组。治疗组患者在诊所接受常规生物膜剥脱手术，而对照组患者则不进行生物膜去除手术。本研究中仅放置了传统的通气管。结果测量是管位置和通畅性。记录管保留时间和任何并发症。
结果
8 名已去除生物膜的患者和 8 名未去除生物膜的患者作为对照组纳入了该研究。治疗组鼓膜置管保留时间（43.5±26.4个月）明显长于对照组（9.5±6.9个月）（P = 0.003）。在随访期间，发现治疗组比对照组有更多的鼓室造口管处于开放状态且位置正确（P = 0.01）。
结论
尽管使用短期通气管，但对于接受鼓膜切开术的患者，直接去除生物膜对于鼓膜造口通气管的长期保留是一种耐受性良好且有效的治疗方法。
BACKGROUND
Although long-term retention of a ventilation tube is required in many ear diseases, spontaneous removal of conventional ventilation tube is observed in patients within 3 to 12 mo. To address this issue, we aimed to determine a new method for long-term retention of the ventilation tube.
AIM
To explore the value of removing the biofilm for long-term retention of tympanostomy ventilation tubes.
METHODS
A case-control study design was used to evaluate the safety and effectiveness of long-term tube retention by directly removing the biofilm (via surgical exfoliation) in patients who underwent myringotomy with ventilation tube placement. The patients were randomly divided into two groups: Control group and treatment group. Patients in the treatment group underwent regular biofilm exfoliation surgery in the clinic, whereas those in the control group did not have their biofilm removed. Only conventional ventilation tubes were placed in this study. Outcome measures were tube position and patency. Tube retention time and any complications were documented.
RESULTS
Eight patients with biofilm removal and eight patients without biofilm removal as a control group were enrolled in the study. The tympanostomy tube retention time was significantly longer in the treatment group (43.5 ± 26.4 mo) than in the control group (9.5 ± 6.9 mo) (P = 0.003). More tympanostomy tubes were found to be patent and in correct position in the treatment group during the follow-up intervals than in the control group (P = 0.01).
CONCLUSION
Despite the use of short-term ventilation tubes, direct biofilm removal can be a well-tolerated and effective treatment for long-term tube retention of tympanostomy ventilation tubes in patients who underwent myringotomy.