Effector Specialization in a Lineage of the Irish Potato Famine Pathogen
Effector Specialization in a Lineage of the Irish Potato Famine Pathogen
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DOI：
10.1126/science.1246300
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发表时间：
2014-01-31
期刊：
影响因子：
56.9
通讯作者：
Kamoun, Sophien
中科院分区：
文献类型：
--
作者：
Dong, Suomeng;Stam, Remco;Kamoun, Sophien
加速的基因进化是病原体在宿主跳跃后适应的标志。在这里，我们描述了适应和专业化的植物病原体效应后，其殖民化的一个新的主机的生化基础。来自爱尔兰马铃薯饥荒病原体致病疫霉及其姊妹种奇异疫霉（Phytophthora mirabilis）（其负责紫茉莉的感染）的邻苯二甲酸酯蛋白酶抑制剂效应物适应于其各自宿主植物特有的蛋白酶靶标。抑制剂及其靶蛋白酶的氨基酸多态性支持这种生物化学特化。我们的研究结果链接效应器专业化的多样化和物种形成的这种植物病原体。
Accelerated gene evolution is a hallmark of pathogen adaptation following a host jump. Here, we describe the biochemical basis of adaptation and specialization of a plant pathogen effector after its colonization of a new host. Orthologous protease inhibitor effectors from the Irish potato famine pathogen, Phytophthora infestans, and its sister species, Phytophthora mirabilis, which is responsible for infection of Mirabilis jalapa, are adapted to protease targets unique to their respective host plants. Amino acid polymorphisms in both the inhibitors and their target proteases underpin this biochemical specialization. Our results link effector specialization to diversification and speciation of this plant pathogen.