Reduced striatal volume in cocaine-dependent patients
Reduced striatal volume in cocaine-dependent patients
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DOI：
10.1016/j.neuroimage.2011.02.035
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发表时间：
2011-06-01
期刊：
影响因子：
5.7
通讯作者：
Avila, Cesar
中科院分区：
文献类型：
--
作者：
Barros-Loscertales, Alfonso;Garavan, Hugh;Avila, Cesar
长期吸食可卡因与大脑结构和功能的变化有关。虽然关于可卡因使用和依赖的动物文献传统上集中在纹状体上，但之前使用基于体素的形态测量学的人类研究报告称，几个大脑区域的灰质体积减少，但纹状体的灰质体积却没有减少。对 20 名可卡因依赖患者和 16 名年龄、教育程度和智力均匹配的健康对照男性进行了脑部磁共振成像。与对照组相比，可卡因依赖组的纹状体和右侧缘上回灰质体积较低。在可卡因依赖组中，可卡因使用年限与双侧额中回、左额上回的体积呈负相关。海马旁回、后扣带回。杏仁核、岛。右颞中回和小脑。这些结果表明，可卡因依赖与多巴胺能系统目标结构中灰质体积的减少有关。这些发现首次表明，通过体素-Basecl形态测定法，人类使用者的纹状体灰质减少，从而将人类结果与成瘾动物模型联系起来。此外，使用年限与许多大脑区域灰质体积之间的关系与可卡因使用导致的灰质体积减少一致。 (C) 2011 Elsevier Inc. 保留所有权利。
Long-term cocaine consumption is associated with brain structural and functional changes. While the animal literature on cocaine use and dependence has traditionally focused on the striatum, previous human studies using voxel-based morphometry have reported reduced volumes of gray matter in several brain areas, but not in the striatum. Brain magnetic resonance imaging was performed with 20 cocaine-dependent patients and 16 healthy age-, education- and intelligence-matched control men. The cocaine-dependent group had lower gray matter volumes in the striatum and right supramarginal gyrus compared to controls. Within the cocaine-dependent group, years of cocaine use were inversely associated with the volume of the bilateral middle frontal gyms, left superior frontal gyrus. parahippocampus, posterior cingulate. amygdala, insula. right middle temporal gyrus and cerebellum. These results show that cocaine dependence is associated with reduced gray matter volumes in the target structures of the dopaminergic system. These findings are the first to suggest reduced gray matter in the striatum by means of voxel-basecl morphometry in human users, thereby linking human results to animal models of addiction. In addition, the relationship between years of use and gray matter volumes in numerous brain regions are consistent with these volume reductions arising as a consequence of the cocaine use. (C) 2011 Elsevier Inc. All rights reserved.