Effect of corneal polarization axis on assessment of retinal nerve fiber layer thickness by scanning laser polarimetry
Effect of corneal polarization axis on assessment of retinal nerve fiber layer thickness by scanning laser polarimetry
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DOI：
10.1016/s0002-9394(00)00353-6
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发表时间：
2000-06-01
影响因子：
4.2
通讯作者：
Huang, XR
中科院分区：
文献类型：
--
作者：
Greenfield, DS;Knighton, RW;Huang, XR
目的：扫描激光偏振仪使用一个前段补偿装置，假定一个固定的角膜双折射轴，我们称之为角膜偏振轴。方法：建立了一套非侵入性的裂隙灯安装装置，用于测量角膜双折射的慢轴。正常受试者进行了角膜偏振轴的测量，扫描激光偏振仪测量了视网膜周围神经纤维层(n=32)和黄斑(n=29)，并对每组进行了迟滞测量。结果：63例118眼(女性35例，黄斑29例)28例男性)行角膜极化轴测量，平均年龄45.5±17.1岁，6只眼(5.1%)未测得角膜偏振度。在其余112只眼中，角膜极化轴分布模式为鼻下10-20度(鼻下90度-鼻上54度)，对侧眼之间存在显著的相关性(P<；0.0001)(R-2=.52)，平均相差11.2+/-10.5度(范围0-52度)。角膜极化轴与视网膜神经纤维层和黄斑发育迟缓参数(平均厚度、椭圆形平均、上下平均、上界和总积分)显著相关(R-2=0.52-0.84)。结论：正常角膜的平均极化轴是鼻侧向下的；但存在相当大的个体内和个体间的差异，角膜极化轴与后段延迟参数之间的线性关系部分是由Elsevier Science Inc.(C)2000扫描激光偏振仪产生的视网膜神经纤维层厚度数据广泛分布的原因，所有权利保留。
PURPOSE: Scanning laser polarimetry uses an anterior segment: compensating device that assumes a fixed axis of corneal birefringence, which we call the corneal polarization axis. The purpose of this investigation was to establish the distribution of corneal polarization axes among a population of normal eyes and to evaluate the relationship between corneal polarization axis and posterior segment retardation.METHODS: We constructed a noninvasive slit lamp-mounted device incorporating two crossed linear polarizers and an optical retarder in order to measure the slow axis of corneal birefringence, Normal subjects underwent corneal polarization axis measurement, A subset of eyes underwent scanning laser polarimetry of the peripapillary retinal nerve fiber layer (n = 32) and macula (n = 29), and retardation measurements were evaluated in each group,RESULTS: One hundred eighteen eyes of 63 normal subjects (35 female, 28 male) underwent corneal polarization axis measurement (mean age, 45.5 +/- 17,1 years), Six eyes (5.1%) demonstrated unmeasurable corneal polarization. In the remaining 112 eyes, the mode of the corneal polarization axis distribution was 10 to 20 degrees nasally downward (range, 90 degrees nasally downward to 54 degrees nasally upward), A significant (P < .0001) correlation was observed between fellow eyes (R-2 = .52), with a mean difference of 11.2 +/- 10.5 degrees (range, 0-52 degrees). Corneal polarization axis was significantly associated (R-2 =.52-.84) with retinal nerve fiber layer and macula summary retardation parameters (average thickness, ellipse average, superior and inferior average, superior and total integral; P < .0001 for all groups).CONCLUSIONS: The mean corneal polarization axis among normal corneas is nasally downward; however, considerable intraindividual and interindividual variability exists, The linear relationship between corneal polarization axis and posterior segment retardation parameters is responsible, in part, for the wide distribution of retinal nerve fiber layer thickness data generated by scanning laser polarimetry, (C) 2000 by Elsevier Science Inc, All rights reserved.