Hemodynamic responses to visual stimulation in children with sickle cell anemia.
Hemodynamic responses to visual stimulation in children with sickle cell anemia.
复制标题
镰状细胞性贫血儿童对视觉刺激的血流动力学反应。
DOI：
10.1007/s11682-011-9133-4
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发表时间：
2011
影响因子：
3.2
通讯作者：
Ogg,RobertJ
中科院分区：
文献类型：
--
作者：
Zou,Ping;Helton,KathleenJ;Smeltzer,Matthew;Li,Chin-Shang;Conklin,HeatherM;Gajjar,Amar;Wang,WinfredC;Ware,RussellE;Ogg,RobertJ
采用血氧水平依赖性（BOLD）和基于脑血流量（CBF）的功能磁共振成像（fMRI）检测了23例镰状细胞性贫血（SCA）儿童（12.4 ± 0.7岁）和21例临床对照儿童（11 ± 1.0岁）的初级视皮层对光刺激的反应。本研究的目的是探讨SCA对功能磁共振成像（fMRI）检测脑激活的影响，以及fMRI反应与整体认知功能的关系。在SCA儿童中BOLD反应减少。在没有检测到视觉皮层激活的患者中，疾病严重程度的临床指标最高，但血液血红蛋白浓度和静息CBF不能预测SCA患者的BOLD信号幅度。出乎意料的是，BOLD信号幅度与韦氏简明智力量表评分呈正相关（rs≥ 0. 8，p ≤ 0. 05），表明fMRI可能有助于阐明介导SCA对神经认知功能不良影响的医学、血流动力学和神经因素。
Blood oxygenation level-dependent (BOLD) and cerebral blood flow (CBF)-based functional magnetic resonance imaging (fMRI) were used to measure primary visual cortex responses to photic stimulation in 23 children (12.4 ± 0.7 years old) with sickle cell anemia (SCA) and 21 clinical controls (11 ± 1.0 years old). The objectives were to investigate the effect of SCA on detection of brain activation with fMRI and to explore the relationship between fMRI responses and global cognitive function. The BOLD responses were diminished in children with SCA. Clinical indicators of disease severity were greatest in patients without detectable visual cortex activation, but blood hemoglobin concentration and resting CBF were not predictive of BOLD signal amplitude in the SCA patients. Unexpectedly, the BOLD signal amplitude was positively associated (rs≥ 0.8,p≤ 0.05) with Wechsler Abbreviated Scale of Intelligence scores, suggesting that fMRI may help clarify medical, hemodynamic, and neural factors that mediate adverse effects of SCA on neurocognitive function.