Phosphoinositide signaling during membrane transport in Saccharomyces cerevisiae.
Phosphoinositide signaling during membrane transport in Saccharomyces cerevisiae.
复制标题
酿酒酵母膜转运过程中的磷酸肌醇信号传导。
DOI：
10.1007/978-94-007-3015-1_2
复制
发表时间：
2012
影响因子：
--
通讯作者：
Audhya,Anjon
中科院分区：
文献类型：
--
作者：
Schuh,AmberL;Audhya,Anjon
磷脂酰肌醇 (PI) 与其他磷脂不同，其头部基团可通过多个位置的磷酸化进行修饰，产生独特的信号分子，统称为磷酸肌醇。调节 PI 代谢的一组激酶和磷酸酶在真核进化过程中是保守的，大量研究表明磷酸肌醇调节多种细胞过程，包括囊泡运输、细胞增殖和细胞骨架组织。在过去的二十年中，几乎所有 PI 衍生物都已被证明可以直接与细胞蛋白相互作用，从而影响其定位和/或活性。此外，越来越多的证据表明磷酸肌醇也可能影响局部膜拓扑结构。在这里，我们重点关注磷酸肌醇在膜运输中的作用，并强调酵母在该领域发挥的重要作用。
Phosphatidylinositol (PI) is distinct from other phospholipids, possessing a head group that can be modified by phosphorylation at multiple positions to generate unique signaling molecules collectively known as phosphoinositides. The set of kinases and phosphatases that regulate PI metabolism are conserved throughout eukaryotic evolution, and numerous studies have demonstrated that phosphoinositides regulate a diverse spectrum of cellular processes, including vesicle transport, cell proliferation, and cytoskeleton organization. Over the past two decades, nearly all PI derivatives have been shown to interact directly with cellular proteins to affect their localization and/or activity. Additionally, there is growing evidence, which suggests that phosphoinositides may also affect local membrane topology. Here, we focus on the role of phosphoinositides in membrane trafficking and underscore the significant role that yeast has played in the field.