Management of oral mucositis in patients who have cancer.
Management of oral mucositis in patients who have cancer.
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DOI：
10.1016/j.cden.2007.10.002
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发表时间：
2008-01-01
影响因子：
--
通讯作者：
Peterson, Douglas E
中科院分区：
文献类型：
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作者：
Lalla, Rajesh V;Sonis, Stephen T;Peterson, Douglas E
口腔粘膜炎是临床上重要的并且有时是癌症治疗的剂量限制性并发症。粘膜炎病变可能是痛苦的，影响营养和生活质量，并有显着的经济影响。口腔粘膜炎的发病机制是多因素且复杂的。本文综述了粘膜炎的发病率、经济影响、发病机制和临床过程。目前口腔粘膜炎的临床管理主要集中在姑息措施，如疼痛管理，营养支持和保持良好的口腔卫生。然而，几种有前途的治疗药物正处于治疗口腔粘膜炎的临床开发的不同阶段。这些代理商进行了讨论的背景下，最近更新的循证临床管理指南。
Oral mucositis is a clinically important and sometimes dose-limiting complication of cancer therapy. Mucositis lesions can be painful, affect nutrition and quality of life, and have a significant economic impact. The pathogenesis of oral mucositis is multifactorial and complex. This review discusses the morbidity, economic impact, pathogenesis and clinical course of mucositis. Current clinical management of oral mucositis is largely focused on palliative measures such as pain management, nutritional support and maintenance of good oral hygiene. However, several promising therapeutic agents are in various stages of clinical development for the management of oral mucositis. These agents are discussed in the context of recently updated evidence-based clinical management guidelines.