Ca(v)2 channels mediate low and high voltage-activated calcium currents in Drosophila motoneurons.
Ca(v)2 channels mediate low and high voltage-activated calcium currents in Drosophila motoneurons.
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Ca(v)2 通道介导果蝇运动神经元中低电压和高电压激活的钙电流。
DOI：
10.1113/jphysiol.2011.222836
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Duch,Carsten
中科院分区：
文献类型：
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作者：
Ryglewski,Stefanie;Lance,Kimberly;Levine,RichardB;Duch,Carsten
关键点·大脑中的神经元表达多种离子通道，以赋予特定的功能特性。·已知至少有三种不同的电压门控钙通道基因家族，每一种都被认为产生具有独特特性的钙通道，这些特性反过来又不同地影响神经元功能。在这里，我们使用遗传模型系统来确定哪些基因负责已识别的运动神经元中的钙电流。·令人惊讶的是，相同的离子通道基因编码两种具有根本不同性质的不同电流，数据还表明，这种钙通道基因的正常功能受到另一种基因表达的影响。这些结果提供了深入了解基因表达和离子电流之间的关系，从而进入正常神经元功能的调节。
Key points•Neurons in the brain express a diversity of ion channels to impart specialized functional properties.•At least three distinct voltage gated calcium channel gene families are known, each of which is thought to produce calcium channels with unique properties, which in turn, differently affect neuronal function.•Here we use a genetic model system to determine which genes are responsible for the calcium currents in an identified motoneuron.•Surprisingly, the same ion channel gene encodes two distinct currents with fundamentally different properties, and the data also suggest that the normal function of this calcium channel gene is affected by the expression of another one.•The results provide insights into the relationship between gene expression and ionic currents, and thus, into the regulation of normal neuronal function.