Gender differences of inducible nitric oxide production in SJL/J mice with experimental autoimmune encephalomyelitis
Gender differences of inducible nitric oxide production in SJL/J mice with experimental autoimmune encephalomyelitis
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DOI：
10.1016/s0165-5728(97)00065-9
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发表时间：
1997-07-01
影响因子：
3.3
通讯作者：
Voskuhl, RR
中科院分区：
文献类型：
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作者：
Ding, MZ;Wong, JL;Voskuhl, RR
我们确定了实验性自身免疫性脑脊髓炎 (EAE) 小鼠中诱导型一氧化氮合酶 (iNOS) 表达和 NO 产生的性别相关差异。当来自雌性小鼠的髓磷脂碱性蛋白特异性 T 淋巴细胞被转移时，雌性受体比雄性受体出现更严重的 EAE，并且表达更高水平的 iNOS 和 NO。当来自男性的T淋巴细胞被转移时，女性和男性受体中均未诱导出严重的EAE，并且iNOS和NO均未检测到。这些数据显示 NO 产生与 EAE 严重程度之间存在关联，表明 NO 在 EAE 发病机制中可能发挥作用。
We identified gender related differences of inducible nitric oxide synthase (iNOS) expression and NO production in mice with experimental autoimmune encephalomyelitis (EAE). When myelin basic protein-specific T-lymphocytes derived from female mice were transferred, the female recipients developed more severe EAE and expressed higher levels of iNOS and NO than male recipients. When the T-lymphocytes derived from males were transferred, severe EAE was induced in neither female nor male recipients and neither iNOS nor NO were detectable. These data show an association between NO production and EAE severity, suggesting a possible role of NO in the pathogenesis of EAE.