The role of sex in parasite dynamics:: Model simulations on transmission of Heligmosomoides polygyrus in populations of yellow-necked mice, Apodemus flavicollis
The role of sex in parasite dynamics:: Model simulations on transmission of Heligmosomoides polygyrus in populations of yellow-necked mice, Apodemus flavicollis
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DOI：
10.1016/j.ijpara.2006.10.015
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发表时间：
2007-03-01
影响因子：
4
通讯作者：
Hudson, P. J.
中科院分区：
文献类型：
--
作者：
Ferrari, N.;Rosa, R.;Hudson, P. J.
我们研究了可能的机制，可能会导致性别偏见的寄生虫传播的蠕虫Helignioson ides polygyrus在其啮齿动物宿主，黄颈姬鼠，使用建模方法。两个，不相互排斥，假设进行了检查：性别偏见的寄生虫传播是由免疫力的差异，影响成功的自由生活阶段和/或由性别差异造成的主机行为和传播的感染阶段。模型模拟结果与H.多脑回在A.黄颈模拟预测了实验场的结果，这两种假设解释了观察到的模式。如果男性免疫反应增加生育力、孵化或自由生活阶段的存活，则传播偏向男性。或者，如果它们的行为特征允许它们在雌性更经常使用的区域传播感染性幼虫，则传播偏向于雄性。这些结果强调，宿主性别不仅是负责寄生虫易感性的差异，但可能会深刻地影响宿主-寄生虫的相互作用，导致寄生虫传播的性别偏见。(c)2006年澳大利亚寄生虫学会由爱思唯尔有限公司出版。保留所有权利。
We investigated possible mechanisms that could cause sex-biased parasite transmission of the helminth Helignioson to ides polygyrus in its rodent host, Apodemus flavicollis, using a modelling approach. Two, not mutually exclusive, hypotheses were examined: that sex-biased parasite transmission is caused by differences in immunity that influence the success of free-living stages and/or is caused by sex differences in host behaviour and the dissemination of infective stages. Model simulations were compared with results from a field manipulation experiment of H. polygyrus in replicated populations of A. flavicollis. Simulations predicted the experimental field results, and both hypotheses explained the pattern observed. Transmission is male-biased if a male immune response increases fertility, hatching or survival of free-living stages. Alternatively, transmission is male-biased if their behavioural characteristics allow them to spread infective larvae in areas more frequently used by females. These results highlight that host sex is not only responsible for differences in parasite susceptibility, but may profoundly influence host-parasite interactions, resulting in a sex bias in parasite transmission. (c) 2006 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.