Chiral Gold Phosphate Catalyzed Tandem Hydroamination/Asymmetric Transfer Hydrogenation Enables Access to Chiral Tetrahydroquinolines
Chiral Gold Phosphate Catalyzed Tandem Hydroamination/Asymmetric Transfer Hydrogenation Enables Access to Chiral Tetrahydroquinolines
复制标题
手性磷酸金催化串联氢胺化/不对称转移氢化能够获得手性四氢喹啉
DOI：
10.1021/acs.joc.5b00153
复制
发表时间：
2015-05-01
影响因子：
3.6
通讯作者：
Gong, Liu-Zhu
中科院分区：
文献类型：
--
作者：
Du, Yu-Liu;Hu, Yue;Gong, Liu-Zhu
描述了一种高效手性磷酸金催化的串联氢胺化/不对称转移加氢反应。得到了一系列手性四氢喹啉，收率高，对映选择性好。在该反应中，金催化剂使氢胺化步骤成为pi-Lewis酸，并使不对称氢转移过程成为有效的手性Lewis酸。
A highly efficient chiral gold phosphate-catalyzed tandem hydroamination/asymmetric transfer hydrogenation reaction is described. A series of chiral tetrahydroquinolines were obtained in excellent yields and enantioselectivities. In this reaction, the gold catalyst enables both the hydroamination step as a pi-Lewis acid and the asymmetric hydrogen-transfer process as an effective chiral Lewis acid.