Simulation of acute reference dose (ARfD) settings for pesticides in Japan.
Simulation of acute reference dose (ARfD) settings for pesticides in Japan.
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日本农药急性参考剂量 (ARfD) 设置的模拟。
DOI：
10.2131/jts.38.205
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发表时间：
2013
期刊：
影响因子：
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通讯作者：
A. Ono
中科院分区：
文献类型：
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作者：
Midori Yoshida;D. Suzuki;Kiyoshi Matsumoto;M. Shirota;Kaoru Inoue;Miwa Takahashi;T. Morita;A. Ono
为了制定日本农药急性参考剂量（ARfD）设定指南，我们根据日本食品安全委员会（FSC）在过去8年中评估的201种农药的评估报告，对ARfD设定进行了模拟。我们的概念原则基于Solecki等人（2005）编写的概念，并根据日本要求的毒理学数据进行了调整。通过这一过程，我们能够为测试的201种农药中超过90%设定ARfD。提供急性参考剂量设定依据的研究主要是生殖和发育毒性研究、急性神经毒性研究和药理学研究。对于本研究中模拟的大约30%的农药，没有必要确定急性参考剂量。由于评价报告是针对可接受的每日摄入量设定编写的，因此根据其终点得出的一些模拟急性参考剂量可能是保守估计值。因此，有时很难区分急性毒性警报和反复毒性。由于急性毒性数据不足，我们无法为14种农药设定急性参考剂量。这可以通过更完整的记录来改善。此外，我们还根据作用机制或化学结构对201种农药进行了分类。我们的模拟表明，这里提出的概念框架可以作为一个基础，在日本的农药急性参考剂量设置的指导方针的发展。
In order to develop guidelines for setting acute reference doses (ARfDs) for pesticides in Japan, we conducted simulations of ARfD settings based on evaluation reports for 201 pesticides assessed by the Food Safety Commission (FSC) in Japan over the last 8 years. Our conceptual principles were based on the concepts written by Solecki et al. (2005) and were adapted for toxicological data required in Japan. Through this process, we were able to set the ARfDs for over 90% of the 201 pesticides tested. The studies that provided the rationale for ARfD setting were primarily reproductive and developmental toxicity studies, acute neurotoxicity studies, and pharmacology studies. For approximately 30% of the pesticides simulated in the present study, it was not necessary to establish ARfDs. Some of the simulated ARfDs resulting from their endpoints may be conservative estimates, because the evaluation reports were written for acceptable daily intake settings. Thus, it was sometimes difficult to distinguish acute toxic alerts from repeated toxicities. We were unable to set an ARfD for 14 pesticides because of insufficient data on acute toxicities. This could be improved by more complete recordkeeping. Furthermore, we categorized the 201 pesticides by mechanism of action or chemical structure. Our simulation indicates that the conceptual framework presented here can be used as a basis for the development of guidelines on ARfD settings for pesticides in Japan.