Titanium and Zirconium Mediated or Catalyzed Umpolung Reactions
Titanium and Zirconium Mediated or Catalyzed Umpolung Reactions
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DOI：
10.1002/chin.200951230
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发表时间：
2008-10
期刊：
影响因子：
--
通讯作者：
Hairong Guan
中科院分区：
文献类型：
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作者：
Hairong Guan
本文综述了目前使用钛和锆试剂实现羰基和亚胺官能团分析的策略。有机金属化合物的反应，包括那些相当于酰基阴离子、α-氨基碳离子、α-羟基碳离子和同源烯醇酸盐的反应，是形成碳-碳键的最有效方法之一。在许多情况下观察到的显著的化学选择性、区域选择性和立体选择性再次证明了有机钛和有机锆化合物的巨大合成应用。
This review presents current strategies of using titanium and zirconium reagents to achieve umpolung of carbonyl and imine functionalities. The reactions of organometallic compounds, including those that are equivalent to acyl anions, α-amino carbanions, α-hydroxy carbanions, and homoenolates, are among the most powerful methods to form carbon-carbon bonds. The remarkable chemoselectivity, regioselectivity, and stereoselectivity observed in many cases once more demonstrate great synthetic application of organotitanium and organozirconium compounds.