Transcranial direct current stimulation applied over the somatosensory cortex -: Differential effect on low and high frequency SEPs
Transcranial direct current stimulation applied over the somatosensory cortex -: Differential effect on low and high frequency SEPs
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DOI：
10.1016/j.clinph.2006.07.136
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发表时间：
2006-10-01
影响因子：
4.7
通讯作者：
Gobbele, Rene
中科院分区：
文献类型：
--
作者：
Dieckhoefer, Anne;Waberski, Till Dino;Gobbele, Rene
目的：经颅直流电刺激（tDCS）对经颅磁刺激后运动诱发电位（MEP）测量的人类运动皮层兴奋性有影响。研究了体感诱发电位（SEPs）的低频和高频（HFO）成分，质疑将tDCS应用于人类体感皮质后是否可以观察到类似的效果。方法：在9分钟内应用1 mA的tDCS之前和之后记录多通道正中神经SEP，阴极置于体感皮层上，阳极置于对侧前额上，反之亦然。第二次会议。结果：在对躯体感觉皮层进行阴极tDCS刺激后，N20、N30和HFOs的源性活动显著降低，而阳极刺激后无明显影响。对于N30组件和HFOs源activitywere observed.Conclusions：相应的结果为运动皮层的持续减少后阴极tDCS.Significance的躯体感觉皮层的兴奋性：我们证明了差异效应tDCS上的高，低频率成分的SEP确认这两个组件的本地和功能不同的发电机的假设。(c)2006年国际临床神经生理学联合会。由Elsevier爱尔兰有限公司出版。保留所有权利。
Objective: Transcranial direct current stimulation (tDCS) has an influence on the excitability of the human motor cortex measured by motor evoked potentials (MEPs) after transcranial magnetic stimulation. Low and high frequency (HFOs) components of somatosensory evoked potentials (SEPs) were studied questioning whether a comparable effect can be observed after applying tDCS to the human somatosensory cortex.Methods: Multichannel median nerve SEPs were recorded before and after applying tDCS of 1 mA over a period of 9 min with the cathode placed over the somatosensory cortex and the anode over the contralateral forehead and vice versa in a second session. The source activity of the N20, N30 and HFOs was evaluated before and after application of tDCS.Results: After cathodal tDCS to the somatosensory cortex we found a significant reduction of the N20 source amplitude while there was no effect after anodal stimulation. For the N30 component and HFOs no change in source activity was observed.Conclusions: Corresponding to the results for the motor cortex a sustained reduction of the excitability of the somatosensory cortex after cathodal tDCS was shown.Significance: We demonstrated differential effects of tDCS on the high and low frequency components of SEPs confirming the hypothesis of locally and functionally distinct generators of these two components. (c) 2006 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.