Evaluation of the degree of pancreatic fatty infiltration by area-based assessment of CT images: comparison with histopathology-based and CT attenuation index-based assessments
Evaluation of the degree of pancreatic fatty infiltration by area-based assessment of CT images: comparison with histopathology-based and CT attenuation index-based assessments
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DOI：
10.1007/s11604-016-0572-0
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发表时间：
2016-10-01
影响因子：
2.1
通讯作者：
Nakagama, Hitoshi
中科院分区：
文献类型：
--
作者：
Hori, Mika;Onaya, Hiroaki;Nakagama, Hitoshi
本研究的目的是利用基于CT的面积评估(CT-BASE-BASE)来评估胰腺的脂肪渗透(FI)程度及其与组织病理学评估的一致性/一致性。此外，我们还检查了基于CT面积的评估是否优于基于CT衰减指数的评估。我们回顾评估了37例胰腺癌患者术前接受CT和胰腺十二指肠切除术后的FI程度。通过手术切除标本的组织病理学评估、基于CT面积的评估和基于CT衰减指数的评估来评估胰腺的FI程度，平扫基于区域的评估和基于组织病理学的评估的平均值分别为14.4+/-23.2%(范围0-77.7%)和16.2+/-17.4%(范围0.2-60.2%)。平扫CT的区域评估与组织病理学评估有较高的相关性和一致性，Spearman相关系数为0.78(P<；0.0001)，Kendall‘s tau-b系数为0.69(P<；0.0001)。基于CT衰减指数的评估，对应值分别为-0.66(P<；0.0001)和-0.39(P=0.008)。根据胰腺FI的程度对受试者进行排序/分类，基于CT面积的评估优于基于CT衰减指数的评估。
The purpose of this study was to evaluate the degree of fatty infiltration (FI) of the pancreas using area-based assessment on computed tomography (CT) (CT area-based assessment) in its correlation and agreement/concordance with histopathology-based assessment. Furthermore, we examined whether CT area-based assessment was better than CT attenuation index-based assessment.We retrospectively evaluated the degree of FI of the pancreas in 37 pancreatic cancer patients who had undergone preoperative CT and pancreaticoduodenectomy. The degree of FI of the pancreas was examined by histopathology-based assessment using surgical resection samples, and CT area-based and CT attenuation index-based assessments.Mean values of pancreatic FI measured by area-based assessment on unenhanced CT and by histopathology-based assessments were 14.4 +/- 23.2 % (range 0-77.7 %) and 16.2 +/- 17.4 % (range 0.2-60.2 %), respectively. Area-based assessment on unenhanced CT showed higher correlation and concordance with histopathology-based assessment, demonstrating a Spearman correlation coefficient of 0.78 (P < 0.0001) and a Kendall's tau-b coefficient of 0.69 (P < 0.0001). For CT attenuation index-based assessment, the corresponding values were -0.66 (P < 0.0001) and -0.39 (P = 0.008), respectively.To order/categorize subjects according to the degree of FI of the pancreas, CT area-based assessment is suggested to be better than CT attenuation index-based assessment.