Efect of longitudinally oriented collagen conduit combined with nerve growth factor on nerve regeneration after dog sciatic nerve injury.
Efect of longitudinally oriented collagen conduit combined with nerve growth factor on nerve regeneration after dog sciatic nerve injury.
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DOI：
10.1002/jbm.b.34020
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发表时间：
2018-08
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通讯作者：
Yao Yao-Yao;Yi Cui;Yannan Zhao;Zhifeng Xiao;Xing Li;Sufang Han;Bing Chen;Yongxiang Fang;Piao Wang;J. Pan;Jianwu Dai
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作者：
Yao Yao-Yao;Yi Cui;Yannan Zhao;Zhifeng Xiao;Xing Li;Sufang Han;Bing Chen;Yongxiang Fang;Piao Wang;J. Pan;Jianwu Dai
人工神经导管的研究已成为周围神经重建研究的热点，有望替代临床上自体神经移植的治疗。在本研究中，我们使用纵向胶原导管（LOCC）结合神经生长因子（NGF）来重建成年犬的长距离坐骨神经缺损（35毫米）模型。长期随访评估表明，LOCC/NGF 导管允许受损坐骨神经横断部位的功能和形态神经再生。此外，功能研究证实，当 NGF 加载到 LOCC 上时，它比单独的 LOCC 更好地促进再生轴突的恢复。 LOCC/NGF 组的腓肠肌质量显着大于单独 LOCC 组。结果表明，当LOCC导管与NGF结合时，将为坐骨神经再生提供有利的环境。 © 2017 Wiley periodicals, Inc. J Biomed Mater Res B 部分：Appl Biomater，106B：2131-2139，2018。
The research on artificial nerve conduits has become a focus of study in peripheral nerve reconstruction so as a possible replacement for the treatment of autologous nerve grafts in clinics. In this study, we used longitudinally oriented collagen conduit (LOCC) combined with nerve growth factor (NGF) to reconstruct long distance of sciatic nerve defects (35 mm) in adult dog model. The long term follow-up evaluation demonstrated that the LOCC/NGF conduit allowed functional and morphological nerve regeneration at the transection site of the injured sciatic nerve. Furthermore, the functional study confirmed that when NGF was loaded onto LOCC it promoted a better recovery of regenerated axons than LOCC alone. The gastrocnemius muscle mass in the LOCC/NGF group was significantly greater than in the LOCC alone group. The results indicated that when LOCC conduit combined with NGF it would provide a preferential environment for sciatic nerve regeneration. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2131-2139, 2018.