Stockpiling prepandemic influenza vaccines: a new cornerstone of pandemic preparedness plans
Stockpiling prepandemic influenza vaccines: a new cornerstone of pandemic preparedness plans
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DOI：
10.1016/s1473-3099(08)70232-9
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发表时间：
2008-10-01
影响因子：
56.3
通讯作者：
Nicholson, Karl G.
中科院分区：
文献类型：
--
作者：
Jennings, Lance C.;Monto, Arnold S.;Nicholson, Karl G.
大流行性流感的历史，以及高致病性禽流感A(H5N1)病毒的流行演变和相关人类感染的严重性，向世界发出了另一场流感大流行的威胁的警告。保守的估计表明，多达3.5亿人可能死亡，更多的人将受到影响，对医疗保健系统、社会和世界经济造成破坏。世卫组织鼓励各国通过制定涉及公共卫生和药物干预的流感大流行防备计划，提前做好准备。疫苗接种是这些计划的基石；然而，由于无法预测下一次大流行病毒，因此不能提前生产大流行疫苗。因此，疫苗储备和流行前接种的概念变得很有吸引力。目前已有人用H5N1疫苗，可诱导异型免疫。世卫组织和各国政府应紧急考虑使用这些疫苗，以便在出现H5N1流感大流行时为感染风险最大的个人或社区接种疫苗。
The history of pandemic influenza, along with the evolving epizootic of the highly pathogenic avian influenza A (H5N1) virus and the severity of associated human infections, serve as a warning to the world of the threat of another influenza pandemic. Conservative estimates suggest that up to 350 million people could die and many more would be affected, causing disruption to health-care systems, society, and the world's economy. WHO has encouraged countries to prepare in advance by developing influenza pandemic preparedness plans that involve public-health and pharmaceutical interventions. Vaccination is a cornerstone of these plans; however, a pandemic vaccine cannot be manufactured in advance because the next pandemic virus cannot be predicted. The concepts of vaccine stockpiling and prepandemic vaccination have thus become attractive. Human H5N1 vaccines are currently available and can induce heterotypic immunity. WHO and governments should give urgent consideration to the use of these vaccines for the priming of individuals or communities who would be at greatest risk of infection if an H5N1 influenza pandemic were to emerge.