LYMPHOCYTIC INFILTRATES IN PRIMARY GLIOBLASTOMAS AND RECIDIVOUS GLIOMAS - INCIDENCE, FATE, AND RELEVANCE TO PROGNOSIS IN 228 OPERATED CASES
LYMPHOCYTIC INFILTRATES IN PRIMARY GLIOBLASTOMAS AND RECIDIVOUS GLIOMAS - INCIDENCE, FATE, AND RELEVANCE TO PROGNOSIS IN 228 OPERATED CASES
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DOI：
10.3171/jns.1978.49.6.0854
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发表时间：
1978-01-01
影响因子：
4.1
通讯作者：
GUIDETTI, B
中科院分区：
文献类型：
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作者：
PALMA, L;DILORENZO, N;GUIDETTI, B
几种人类恶性肿瘤中存在的淋巴细胞浸润与生存期延长之间的相关性促使了这项研究。对选定的胶质母细胞瘤手术患者（200例）进行了审查，以调查组织学切片中淋巴细胞浸润的发生率及其与更好的临床病程的可能相关性。有明确淋巴细胞浸润组（A组，11.5%）的术前病史和术后生存率明显长于其他两组（B组，23%; C组，65%）。回顾了28例复发性胶质瘤的活检，以研究这种淋巴细胞浸润与时间和治疗（例如已知会抑制免疫反应的放射和类固醇）的关系。严重的淋巴细胞浸润是一种罕见的免疫生物学反应，可显著改善恶性脑肿瘤的预后，似乎不受时间、局部X线治疗或类固醇的影响。
The correlation existing in several human malignancies between lymphocytic infiltration and prolonged survival prompted this study. Selected patients (200) who were operated on for glioblastoma were reviewed to investigate the incidence of the lymphocytic infiltration in the histological slides and its possible relevance to a better clinical course. The group that exhibited a definite lymphocytic infiltration (Group A, 11.5%) had a significantly longer preoperative history and postoperative survival (P < 0.01) than the other 2 groups that presented slight or no infiltration (Group B, 23%, and Group C, 65%, respectively). Biopsies of 28 recidivous gliomas were reviewed to study the fate of this lymphocytic infiltration in relation to time and therapy, such as irradiation and steroids which are known to depress the immune response. Severe lymphocytic infiltration is a rare immunobiological reaction which significantly improves the prognosis of a malignant brain tumor and seems not to be influenced by time, local X-ray therapy or steroids.