marelle acts downstream of the Drosophila HOP/JAK kinase and encodes a protein similar to the mammalian STATs
marelle acts downstream of the Drosophila HOP/JAK kinase and encodes a protein similar to the mammalian STATs
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DOI：
10.1016/s0092-8674(00)81286-6
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发表时间：
1996-02-09
期刊：
影响因子：
64.5
通讯作者：
Perrimon, N
中科院分区：
文献类型：
--
作者：
Hou, XS;Melnick, MB;Perrimon, N
我们已经确定了一个假定的果蝇STAT蛋白命名为马莱尔，表现出突变表型相同的突变Hopscotch/JAK激酶。我们发现，marelle基因活性的量减少抑制与跳房子功能获得性突变相关的表型，并增强与弱跳房子突变相关的表型。我们建议，跳房子激活马莱尔调节靶基因的转录，如配对规则基因，甚至跳过。我们的研究结果表明存在一个无脊椎动物JAK/STAT系统。
We have identified a putative Drosophila STAT protein named Marelle that exhibits mutant phenotypes identical to mutations in the Hopscotch/JAK kinase. We show that a reduction in the amount of marelle gene activity suppresses the phenotype associated with a gain-of-function mutation in hopscotch and enhances the phenotype associated with a weak hopscotch mutation. We propose that Hopscotch activates Marelle to regulate transcription of target genes such as the pair rule gene even-skipped. Our results demonstrate the existence of an invertebrate JAK/STAT system.