Photodynamic therapy of head and neck squamous cell carcinoma: optical dosimetry and clinical trial.
Photodynamic therapy of head and neck squamous cell carcinoma: optical dosimetry and clinical trial.
复制标题
头颈鳞状细胞癌的光动力治疗：光学剂量测定和临床试验。
DOI：
10.1111/j.1751-1097.1987.tb04868.x
复制
发表时间：
1987
影响因子：
3.3
通讯作者：
Lobraico,RV
中科院分区：
文献类型：
--
作者：
Grossweiner,LI;Hill,JH;Lobraico,RV
本文报告了光动力疗法(PDT)治疗头颈部鳞状细胞癌(HNSCC)的PDT剂量学模型与目前正在进行的临床试验结果的回顾比较。该模型是基于这样的假设，即肿瘤根除需要肿瘤局部的卟啉对辐射能量的最小吸收。采用扩散近似来计算在距离光源最远的肿瘤边界处达到最小吸收能量密度所需的入射光剂量。用估算的组织参数计算HNSCC的剂量表，根据肿瘤的大小给出正面曝光(FS)和间质圆柱形扩散纤维(CI)照射的PDT光剂量。该模型包括对治疗性光对局部光敏剂的光漂白的修正。PDT试验是在9名以前未经治疗或复发的早期肿瘤患者和1名复发的晚期肿瘤患者身上进行的。83%(10/12)的治疗部位完全缓解。计算的FS和CI暴露剂量与每个完全反应肿瘤部位的实际剂量相当，甚至比实际剂量低三倍。
This paper reports the retrospective comparison of a PDT dosimetry model with the current results of an ongoing clinical trial on photodynamic therapy (PDT) for head and neck squamous cell carcinoma (HNSCC). The model is based on the assumption that tumor eradication requires a minimum absorption of radiant energy by the tumor‐localized porphyrins. The diffusion approximation was employed to calculate the incident light dose required to attain the minimum absorbed energy density at tumor boundaries most distant from the light source. Dosimetry tables for HNSCC were calculated with estimated tissue parameters, giving the PDT light dose for front surface exposure (FS) and illumination by interstitial cylindrical diffuser fibers (CI) in terms of the tumor dimensions. The model includes a correction for the photobleaching of the localized photosensitizer by the therapeutic light. The PDT trial was carried out on nine patients with previously untreated or recurrent early stage tumors and one patient with a recurrent advanced stage tumor. A complete response was obtained in 83% (10/12) of the sites treated. The calculated doses for FS and CI exposures vary from comparable with to three‐fold lower than the actual doses for each complete response tumor site.