A Population-Based Study of Pyogenic Liver Abscesses in the United States: Incidence, Mortality, and Temporal Trends
A Population-Based Study of Pyogenic Liver Abscesses in the United States: Incidence, Mortality, and Temporal Trends
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DOI：
10.1038/ajg.2009.614
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发表时间：
2010-01-01
影响因子：
9.8
通讯作者：
Kaplan, Gilaad G.
中科院分区：
文献类型：
--
作者：
Meddings, Liisa;Myers, Robert P.;Kaplan, Gilaad G.
目的：很少有基于人群的研究评估北美的化脓性肝脓肿 (PLA)。我们评估了 PLA 的发生率并评估了死亡率的预测因素。方法：我们使用全国住院患者样本来识别 1994 年至 2005 年间所有因 PLA 出院的患者 (ICD-9 572.0)。进行多变量逻辑回归分析以确定死亡率是否与患者和医院特征（包括合并症、干预措施和细菌培养）相关。我们确定了美国人口中 PLA 的年发病率，并使用广义线性回归模型评估了时间变化。结果：我们确定了 17,787 例 PLA 出院，每 100,000 人的 PLA 总发病率为 3.6（95% 置信区间 (CI)：3.5-3.7）。从 1994 年到 2005 年，发病率年平均增长率为 4.1%（95% CI：3.4-4.8；P
OBJECTIVES: Few population-based studies have evaluated pyogenic liver abscess (PLA) in North America. We assessed the incidence of PLA and evaluated predictors of mortality.METHODS: We used the Nationwide Inpatient Sample to identify all patients with discharges for PLA (ICD-9 572.0) between 1994 and 2005. Multivariable logistic regression analysis was performed to determine whether mortality was associated with patient and hospital characteristics including comorbidities, interventions, and bacterial cultures. We determined the annual incidence for PLA in the US population and assessed for temporal changes using generalized linear regression models.RESULTS: We identified 17,787 PLA discharges for an overall incidence of PLA of 3.6 (95% confidence interval (CI): 3.5-3.7) per 100,000 population. From 1994 to 2005, the annual average percent increase in incidence was 4.1% ( 95% CI: 3.4-4.8; P