Clinical and epidemiological features of acute infantile gastroenteritis associated with human rotavirus subgroups 1 and 2
Clinical and epidemiological features of acute infantile gastroenteritis associated with human rotavirus subgroups 1 and 2
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人轮状病毒1、2亚型相关急性婴儿胃肠炎的临床和流行病学特征
DOI：
10.1128/jcm.23.3.551-555.1986
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发表时间：
1986
影响因子：
9.4
通讯作者：
L. Svensson
中科院分区：
文献类型：
--
作者：
Ingrid UHNOOl;L. Svensson
在一项为期1年的前瞻性研究中，用聚丙烯酰胺凝胶电泳对169例肠胃炎患儿分离的轮状病毒进行了研究。共有118株（70%）所分析的毒株含有足够的病毒核酸以给出可见的电泳图谱；36%的菌株属于1亚群（短型），64%的菌株属于2亚群（长型）。这两个亚群在一年的前7个月以相同的频率共同传播，之后第1亚群轮状病毒完全消失。轮状病毒第二亚群全年均有发生。亚组之间在年龄和性别分布方面没有显著差异。在感染轮状病毒1亚群的儿童中，发烧和体温超过39摄氏度的频率明显更高。腹泻和呕吐在两组患者中发生率相似，但在轮状病毒亚群2的儿童中更为明显。发现第二亚群轮状病毒的三种主要电表型变异中的一种与更强烈的症状、更高的住院率和明显更高的呼吸道症状频率相关；临床表现可能表明这种轮状病毒的电型具有较高的毒力。
During a prospective 1-year study rotavirus isolates from 169 children with gastroenteritis were investigated by polyacrylamide gel electrophoresis. A total of 118 (70%) of the strains analyzed contained sufficient viral nucleic acid to give visible electrophoretic patterns; 36% were identified as strains belonging to subgroup 1 (short patterns), and 64% were identified as strains belonging to subgroup 2 (long patterns). The two subgroups cocirculated at equal frequencies during the first 7 months of the year, after which subgroup 1 rotavirus completely disappeared. Subgroup 2 rotavirus occurred throughout the year. No significant differences between the subgroups in relation to age or sex distribution were observed. Fever and temperatures exceeding 39 degrees C were significantly more frequent in children who shed rotavirus subgroup 1. Diarrhea and vomiting occurred at similar rates in both groups of patients, but were more pronounced in children who shed rotavirus subgroup 2. One of three dominant electropherotypic variants of subgroup 2 rotavirus was found to be associated with more intense symptoms, higher rates of hospitalization, and a significantly higher frequency of respiratory symptoms; the clinical picture may indicate that this rotavirus electropherotype has higher virulence.