The association between financial hardship and amygdala and hippocampal volumes: results from the PATH through life project
The association between financial hardship and amygdala and hippocampal volumes: results from the PATH through life project
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DOI：
10.1093/scan/nsr027
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发表时间：
2012-06-01
影响因子：
4.2
通讯作者：
Anstey, Kaarin J.
中科院分区：
文献类型：
--
作者：
Butterworth, Peter;Cherbuin, Nicolas;Anstey, Kaarin J.
这项研究探讨了童年时期遭受贫困或当前面临经济困难的中年人与未经历此类逆境的人相比，大脑是否存在可察觉的差异。结构磁共振成像（MRI）是“人格与整体健康（PATH）人生研究”的一个方面：这是一项大型纵向社区调查，测量了来自澳大利亚东南部三个队列的健康和幸福状况。该分析考虑了访谈时年龄在44 - 48岁的431名中年人的数据。使用Freesurfer图像分析套件进行体积分割。通过调查访谈收集了社会人口状况、心理健康和认知表现方面的数据。结果显示，在控制了已确定的萎缩风险因素后，报告经济困难的成年人左右海马体和杏仁核的体积比未报告困难的人更小。相比之下，困难与颅内体积之间没有可靠的关联，童年贫困与任何体积测量指标之间也没有可靠关联。经济困难可被视为一种强大的应激源，观察到的结果与以下观点一致：困难通过下丘脑 - 垂体 - 肾上腺轴功能和其他与压力相关的途径影响海马体和杏仁核的体积。
This study examined whether middle-aged adults exposed to poverty in childhood or current financial hardship have detectable brain differences from those who have not experienced such adversity. Structural magnetic resonance imaging (MRI) was conducted as one aspect of the Personality and Total Health (PATH) through life study: a large longitudinal community survey measuring the health and well-being of three cohorts from south-eastern Australia. This analysis considers data from 431 middle-aged adults in the aged 44-48 years at the time of the interview. Volumetric segmentation was performed with the Freesurfer image analysis suite. Data on socio-demographic circumstances, mental health and cognitive performance were collected through the survey interview. Results showed that, after controlling for well-established risk factors for atrophy, adults who reported financial hardship had smaller left and right hippocampal and amygdalar volumes than those who did not report hardship. In contrast, there was no reliable association between hardship and intra-cranial volume or between childhood poverty and any of the volumetric measures. Financial hardship may be considered a potent stressor and the observed results are consistent with the view that hardship influences hippocampal and amygdalar volumes through hypothalamic-pituitary-adrenal axis function and other stress-related pathways.