CHRONIC TOXICITY OF 2 FOOD COLORS BRILLIANT BLUE FCF AND INDIGOTINE
CHRONIC TOXICITY OF 2 FOOD COLORS BRILLIANT BLUE FCF AND INDIGOTINE
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DOI：
10.1016/0041-008x(66)90097-4
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发表时间：
1966-01-01
影响因子：
3.8
通讯作者：
DAVIS, KJ
中科院分区：
文献类型：
--
作者：
HANSEN, WH;FITZHUGH, OG;DAVIS, KJ
将亮蓝FCF（FD & C Blue No. 1）和靛蓝（FD & C Blue No. 2）以0.5%、1.0%、2.0%和5.0%的饮食水平喂给24只Osborne-Mendel大鼠，持续两年。在饲喂2.0%和5.0%靛蓝水平的雄性动物中发生生长抑制。未观察到对存活率、血液学或器官重量的影响。在喂食任何一种颜色的动物中均未观察到显著的病理学变化。五只比格犬接受2.0%的饮食水平，三只犬接受1.0%的亮蓝FCF水平，持续一年。一只狗在2%饮食水平下17天后死亡，另一只在1%水平下46周后死亡。以1.0%和2.0%的饮食水平向比格犬饲喂靛蓝长达两年。2年内，2.0%水平的6只犬中有4只死亡，1.0%水平的4只犬中有1只在濒死状态下被处死。所有死亡均归因于并发病毒感染。无临床体征、肉眼病变或显微镜病理学归因于并发病毒感染。没有任何临床体征、肉眼病变或显微镜病理学归因于摄入亮蓝FCF或靛蓝;但是，由于并发病毒感染导致死亡，因此尚未确定靛蓝的无作用水平。连续两年每周皮下注射30 mg亮蓝FCF或20 mg靛蓝到大鼠体内，在注射部位产生纤维肉瘤。除了一些试验小鼠在注射后立即发生急性惊厥性死亡外，在两年期间未观察到归因于每周皮下注射2.5 mg靛蓝的有害作用。
Brilliant Blue FCF (FD & C Blue No. 1) and Indigotine (FD & C Blue No. 2) were fed to groups of 24 Osborne-Mendel rats for two years at dietary levels of 0.5, 1.0, 2.0, and 5.0%. Growth inhibition occurred in the male animals fed Indigotine at the 2.0 and 5.0% levels. No effect was observed on survival, hematology, or organ weights. No significant pathologic changes were observed in animals fed either color. Five beagle dogs received a dietary level of 2.0%, and three dogs a level of 1.0% of Brilliant Blue FCF for one year. One dog died after 17 days on the 2% dietary level and another died after 46 weeks on the 1% level. Indigotine was fed to beagle dogs for periods up to two years at dietary levels of 1.0 and 2.0%. Four of the six dogs at the 2.0% level died during the two years, and one of the four at the 1.0% level was sacrificed in a moribund condition. All the deaths were attributed to intercurrent virus infections. No clinical signs, gross lesions, or microscopic pathology were attributed to intercurrent virus infections. No clinical signs, gross lesions, or microscopic pathology were attributed to ingestion of Brilliant Blue FCF or Indigotine; however, because of deaths from intercurrent virus infections a no-effect level has not been established for Indigotine. Subcutaneous injections of 30 mg of Brilliant Blue FCF or 20 mg of Indigotine into rats weekly for two years produced fibrosarcomas at the site of injection. Other than acute convulsive deaths of some of the test mice immediately after injection, no deleterious effects attributable to the weekly subcutaneous injection of 2.5 mg of Indigotine were observed over a two-year period.