TRPV1 Channels in Immune Cells and Hematological Malignancies
TRPV1 Channels in Immune Cells and Hematological Malignancies
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DOI：
10.1016/bs.apha.2017.01.002
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发表时间：
2017-01-01
期刊：
影响因子：
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通讯作者：
Geraghty, Dominic P.
中科院分区：
文献类型：
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作者：
Omari, Sofia A.;Adams, Murray J.;Geraghty, Dominic P.
瞬时受体电位香草酸-1（TRPV 1）是负责伤害性、热和机械感觉的TRP通道家族的成员。TRPV 1最初仅与感觉神经元相关，现在已知它存在于几乎所有器官中，包括免疫系统的细胞，其中TRPV 1已被证明在炎症和免疫中发挥关键作用。单核细胞、巨噬细胞和树突状细胞表达TRPV 1，小鼠和人类研究均表明TRPV 1活化可防止内毒素诱导的炎症。相比之下，TRPV 1（和其他TRP通道）似乎是T细胞受体激活所需的有丝分裂原。此外，在来自血液和其他恶性肿瘤的细胞系中的研究表明，TRPV 1的表达/功能改变可能作为新型细胞毒性疗法的靶点。
Transient receptor potential vanilloid-1 (TRPV1) is a member of the TRP family of channels that are responsible for nociceptive, thermal, and mechanical sensations. Originally associated exclusively with sensory neurons, TRPV1 is now known to be present in almost all organs, including cells of the immune system, where TRPV1 has been shown to play a pivotal role in inflammation and immunity. Monocytes, macrophages, and dendritic cells express TRPV1, with both mouse and human studies suggesting that TRPV1 activation protects against endotoxin-induced inflammation. In contrast, TRPV1 (and other TRP channels) appears to be required for T-cell receptor activation by mitogens. Additionally, studies in cell lines derived from hematological and other malignancies suggest altered expression/function of TRPV1 might serve as a target for novel cytotoxic therapies.