Sulfatide and its synthetic analogues recognition by Moraxella catarrhalis
Sulfatide and its synthetic analogues recognition by Moraxella catarrhalis
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DOI：
10.1111/j.1348-0421.2006.tb03873.x
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发表时间：
2006-01-01
影响因子：
2.6
通讯作者：
Ahmed, Kamruddin
中科院分区：
文献类型：
--
作者：
Ozcelik, Pinar;Bezirci, Fatma Betul;Ahmed, Kamruddin
卡他莫拉菌是呼吸道和中耳感染的主要病原体之一。这种细菌附着在人咽上皮细胞表面是感染发病机制的第一步。这项研究表明硫脑苷脂可能作为粘膜炎莫拉氏菌附着在人咽上皮细胞上的结合分子。此外，发现六种不同的合成硫苷脂在10μg/ml的最佳浓度下显着抑制粘膜炎莫拉氏菌的附着。合成硫脑苷脂可能有潜力用作预防卡他莫拉氏菌感染的疗法。
Moraxella catarrhalis is one of the major pathogens of respiratory and middle ear infections. Attachment of this bacterium to the surface of human pharyngeal epithelial cells is the first step in the pathogenesis of infections. This study revealed that sulfatide might act as a binding molecule for the attachment of M. catarrhalis to human pharyngeal epithelial cells. Furthermore, six different synthetic sulfatides were found to inhibit the attachment of M. catarrhalis significantly at an optimum concentration of 10 mu g/ml. Synthetic sulfatides may have the potential to be used as a therapy to prevent M. catarrhalis infections.