The relationship between physical activity and brain responses to pain in fibromyalgia.
The relationship between physical activity and brain responses to pain in fibromyalgia.
复制标题
体育活动与大脑对纤维肌痛疼痛的反应之间的关系。
DOI：
10.1016/j.jpain.2010.12.004
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发表时间：
2011-06
期刊：
影响因子：
--
通讯作者：
Cook DB
中科院分区：
文献类型：
--
作者：
McLoughlin MJ;Stegner AJ;Cook DB
The relationship between physical activity and central nervous system mechanisms of pain in fibromyalgia (FM) is unknown. This study determined whether physical activity was predictive of brain responses to experimental pain in FM using functional magnetic resonance imaging (fMRI). Thirty-four participants (n=16 FM; n=18 Control) completed self-report and accelerometer measures of physical activity and underwent fMRI of painful heat stimuli. In FM patients, positive relationships (p<0.005) between physical activity and brain responses to pain were observed in the dorsolateral prefrontal cortex, posterior cingulate cortex, and the posterior insula, regions implicated in pain regulation. Negative relationships (p<0.005) were found for the primary sensory and superior parietal cortices, regions implicated in the sensory aspects of pain. Greater physical activity was significantly (p<0.05) associated with decreased pain ratings to repeated heat stimuli for FM patients. A similar non-significant trend was observed in controls. In addition, brain responses to pain were significantly (p<0.005) different between FM patients categorized as `low' active and those categorized as `high' active. In controls, positive relationships (p<0.005) were observed in the lateral prefrontal, anterior cingulate and superior temporal cortices and the posterior insula. Our results suggest an association between measures of physical activity and central nervous system processing of pain. Our data suggest that brain responses to pain represent a dynamic process where perception and modulation co-occur and that physical activity plays a role in balancing these processes. Physically active FM patients appear to maintain their ability to modulate pain while those who are less active do not.
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DOI：
10.1097/00005768-199805000-00021
发表时间：
1998-05-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Freedson, PS;Melanson, E;Sirard, J
通讯作者：
Sirard, J
影响因子：
--
作者：
Lawrence, Reva C.;Felson, David T.;Wolfe, Frederick
通讯作者：
Wolfe, Frederick
影响因子：
7.4
作者：
Bingel, U;Lorenz, J;Büchel, C
通讯作者：
Büchel, C
影响因子：
7.4
作者：
GRACELY, RH;MCGRATH, P;DUBNER, R
通讯作者：
DUBNER, R
DOI：
10.1016/j.amjmed.2009.09.006
发表时间：
2009-12-01
期刊：
The American journal of medicine
影响因子：
--
作者：
Clauw, Daniel J
通讯作者：
Clauw, Daniel J