The Expanding Therapeutic Utility of Botulinum Neurotoxins.
The Expanding Therapeutic Utility of Botulinum Neurotoxins.
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DOI：
10.3390/toxins10050208
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发表时间：
2018-05-18
期刊：
影响因子：
4.2
通讯作者：
Krupp J
中科院分区：
文献类型：
--
作者：
Fonfria E;Maignel J;Lezmi S;Martin V;Splevins A;Shubber S;Kalinichev M;Foster K;Picaut P;Krupp J
肉毒神经毒素（BoNT）是一种主要的治疗剂，被许可用于神经系统适应症，如肌张力障碍和痉挛。BoNT家族由梭菌在自然界中产生，包含几种具有不同性质的不同蛋白质。在这篇综述中，我们概述了目前的治疗前景，并探讨了BoNT蛋白作为未来治疗方法的多样性。近年来，在疼痛、偏头痛、膀胱过度活动症、骨关节炎和伤口愈合领域出现了新的适应症。对注射部位远端生物学效应的研究可以为疾病定制的BoNT疗法提供未来的机会。然而，在BoNT的药物开发中存在一些挑战，例如液体和缓释BoNT制剂;以及经皮、经上皮和经上皮递送。配方和交付领域的创新方法以及高度灵敏的分析工具将是下一代BoNT临床产品成功的关键。
Botulinum neurotoxin (BoNT) is a major therapeutic agent that is licensed in neurological indications, such as dystonia and spasticity. The BoNT family, which is produced in nature by clostridial bacteria, comprises several pharmacologically distinct proteins with distinct properties. In this review, we present an overview of the current therapeutic landscape and explore the diversity of BoNT proteins as future therapeutics. In recent years, novel indications have emerged in the fields of pain, migraine, overactive bladder, osteoarthritis, and wound healing. The study of biological effects distal to the injection site could provide future opportunities for disease-tailored BoNT therapies. However, there are some challenges in the pharmaceutical development of BoNTs, such as liquid and slow-release BoNT formulations; and, transdermal, transurothelial, and transepithelial delivery. Innovative approaches in the areas of formulation and delivery, together with highly sensitive analytical tools, will be key for the success of next generation BoNT clinical products.
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影响因子：
3.7
作者：
Bagramyan K;Barash JR;Arnon SS;Kalkum M
通讯作者：
Kalkum M
DOI：
10.1038/nrdp.2016.73
发表时间：
2016-10-13
期刊：
Nature reviews. Disease primers
影响因子：
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作者：
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影响因子：
2.8
作者：
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通讯作者：
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影响因子：
7.4
作者：
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通讯作者：
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