Comprehensive assessment of P21 polymorphisms and lung cancer risk
Comprehensive assessment of P21 polymorphisms and lung cancer risk
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DOI：
10.1007/s10038-007-0222-6
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发表时间：
2008-01-01
影响因子：
3.5
通讯作者：
Park, Jae Yong
中科院分区：
文献类型：
--
作者：
Choi, Yi Young;Kang, Hyo-Kyung;Park, Jae Yong
本研究的目的是全面评估P21基因的潜在功能多态性与肺癌的风险。我们首先确定了27名健康韩国人的P21多态性频率，然后在病例对照研究中根据其频率和单倍型标记状态检查了三种多态性（-2266G > A，S31 R和IVS 2 + 16 G> C）。与携带-2266 GG基因型的个体相比，携带至少一个-2266 A等位基因的个体患肺癌的风险显著降低[校正比值比（OR）= 0.71，95%置信区间（CI）= 0.53-0.95，P = 0.02]。携带31 R或IVS 2 + 16 C等位基因的单倍型（ht 2 -4）与肺癌风险显著降低相关，而单倍型31 S/IVS 2 + 16 G在两个位点均携带野生型等位基因（校正OR = 0.65，95%CI = 0.50-0.83，P = 0.007）]。当-2266A等位基因和ht 2 -4被认为是保护性等位基因时，随着保护性等位基因数量的增加，肺癌的风险以剂量依赖的方式降低（P = 0.0002）。这些结果表明，这三个P21多态性的联合分析可能比单一多态性分析更好地预测肺癌的风险。
The purpose of this study is to comprehensively evaluate potential functional polymorphisms in the P21 gene in relation to the risk of lung cancer. We first determined the frequencies of P21 polymorphisms in 27 healthy Koreans, and then examined three polymorphisms (-2266G > A, S31R, and IVS2 + 16G > C), based on their frequencies and haplotype-tagging status, in a case-control study. Individuals with at least one -2266A allele were at a significantly decreased risk of lung cancer compared with those harboring the -2266 GG genotype [adjusted odds ratio (OR) = 0.71, 95% confidence interval (CI) = 0.53-0.95, P = 0.02). The haplotypes (ht2-4) carrying 31R or IVS2 + 16C alleles were associated with a significantly decreased risk of lung cancer compared with the haplotype 31S/IVS2 + 16G, which carried wild-type alleles at both loci (adjusted OR = 0.65, 95% CI = 0.50-0.83, P = 0.007)]. When the -2266A allele and ht2-4 were considered to be protective alleles, the risk of lung cancer decreased in a dose-dependent manner as the number of protective alleles increased (P = 0.0002). These results suggest that a combined analysis of these three P21 polymorphisms might better predict the risk of lung cancer than the analysis of a single polymorphism.