SERUM BETA-CAROTENE, VITAMIN-A AND VITAMIN-E, SELENIUM, AND THE RISK OF LUNG-CANCER
SERUM BETA-CAROTENE, VITAMIN-A AND VITAMIN-E, SELENIUM, AND THE RISK OF LUNG-CANCER
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DOI：
10.1056/nejm198611133152003
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发表时间：
1986-11-13
影响因子：
158.5
通讯作者：
BROOKMEYER, R
中科院分区：
文献类型：
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作者：
MENKES, MS;COMSTOCK, GW;BROOKMEYER, R
我们使用 1974 年在马里兰州华盛顿县进行的一项大型采血研究中收集的血清，研究了血清维生素 A（视黄醇）、β-胡萝卜素、维生素 E 和硒与肺癌风险的关系。将随后被发现患有肺癌（1975 年至 1983 年）的 99 名患者的血清样本中的营养物质水平与 196 名年龄、性别、年龄、年龄、年龄、年龄、年龄、性别等相匹配的对照者的水平进行了比较。种族、献血月份和吸烟史。观察到血清 β-胡萝卜素与肺鳞状细胞癌风险之间存在很强的负相关性（相对比值，4.30；95% 置信限，1.38 和 13.41）。当所有癌症组织学类型一起考虑时，病例中维生素 E 的平均 (.+-.SD) 水平低于对照组（每升 10.5 .+-. 3.2 与 11.9 .+-. 4.90 毫克）。此外，还发现了风险的线性趋势（P=0.04），因此血清维生素E水平处于最低五分之一的人患肺癌的风险比处于最高五分之一的人高出2.5倍。这些数据支持血清维生素 E 水平低与任何类型肺癌的风险之间以及血清 β-胡萝卜素水平低与肺癌鳞状细胞癌风险之间的关联。
We studied the relation of serum vitamin A (retinol), beta-carotene, vitamin E, and selenium to the risk of lung cancer, using serum that had been collected during a large blood-collection study performed in Washington County, Maryland, in 1974. Levels of the nutrients in serum samples from 99 persons who were subsequently found to have lung cancer (in 1975 to 1983) were compared with levels in 196 controls who were matched for age, sex, race, month of blood donation, and smoking history. A strong inverse association between serum beta-carotene and the risk of squamous-cell carcinoma of the lung was observed (relative odds, 4.30; 95 percent confidence limits, 1.38 and 13.41). Mean (.+-.SD) levels of vitamin E were lower among the cases than the controls (10.5 .+-. 3.2 vs. 11.9 .+-. 4.90 mg per liter), when all histologic types of cancer were considered together. In addition, a linear trend in risk was found (P=0.04), so that persons with serum levels of vitamin E in the lowest quintile had a 2.5 times higher risk of lung cancer than persons with levels in the highest quintile. These data support an association between low levels of serum vitamin E and the risk of any type of lung cancer and between low levels of serum beta-carotene and the risk of squamous-cell carcinoma of the lung.