Innovative Research Design Exploring the Effects of Physical Activity and Genetics on Cognitive Performance in Community-Based Older Adults.
Innovative Research Design Exploring the Effects of Physical Activity and Genetics on Cognitive Performance in Community-Based Older Adults.
复制标题
创新研究设计探索体育活动和遗传学对社区老年人认知表现的影响。
DOI：
10.1123/japa.2014-0221
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发表时间：
2015
影响因子：
1.5
通讯作者：
Rulison,KelliL
中科院分区：
文献类型：
--
作者：
Etnier,JenniferL;Labban,JeffreyD;Karper,WilliamB;Wideman,Laurie;Piepmeier,AaronT;Shih,Chia-Hao;Castellano,Michael;Williams,LaurenM;Park,Se-Yun;Henrich,VincentC;Dudley,WilliamN;Rulison,KelliL
Physical activity is predictive of better cognitive performance and lower risk of Alzheimer’s disease (AD). The apolipoprotein E gene (APOE) is a susceptibility gene for AD with thee4allele being associated with a greater risk of AD. Cross-sectional and prospective research shows that physical activity is predictive of better cognitive performance for those at greater genetic risk for AD. However, the moderating role ofAPOEon the effects of a physical activity intervention on cognitive performance has not been examined. The purpose of this manuscript is to justify the need for such research and to describe the design, methods, and recruitment tactics used in the conductance of a study designed to provide insight as to the extent to which cognitive benefits resulting from an 8-month physical activity program are differentiated byAPOE e4status. The effectiveness of the recruitment strategies and the feasibility of recruitingAPOE e4carriers are discussed.
