pH-Responsive, Functionalizable Spyrocyclic Polycarbonate: A Versatile Platform for Biocompatible Nanoparticles
pH-Responsive, Functionalizable Spyrocyclic Polycarbonate: A Versatile Platform for Biocompatible Nanoparticles
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DOI：
10.1021/acs.biomac.8b00744
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发表时间：
2018-08-01
影响因子：
6.2
通讯作者：
Dove, Andrew P.
中科院分区：
文献类型：
--
作者：
Arno, Maria C.;Brannigan, Ruairi P.;Dove, Andrew P.
聚合物纳米颗粒被广泛研究以增强治疗剂对靶向部位的选择性，以及增加难溶性药物的循环寿命和水溶性。与将货物包封到纳米结构中相反，直接与聚合物主链缀合允许更好地控制负载和选择性触发释放。在这项工作中，我们报告了一个简单的程序，通过开环聚合和随后的聚合后改性策略，以创建可生物降解的聚碳酸酯接枝共聚物纳米粒子。该聚合物设计有pH响应性缩醛键和一个双烯基团，允许通过一系列化学反应进行高效的聚合后修饰，以结合成像剂和增溶臂来指导自组装。为了证明这种方法的潜力，测试了基于聚碳酸酯的纳米颗粒的生物相容性及其在A549和IMR-90细胞系中内化的能力。
Polymeric nanoparticles are widely investigated to enhance the selectivity of therapeutics to targeted sites, as well as to increase circulation lifetime and water solubility of poorly soluble drugs. In contrast to the encapsulation of the cargo into the nanostructures, the conjugation directly to the polymer backbone allows better control on the loading and selective triggered release. In this work we report a simple procedure to create biodegradable polycarbonate graft copolymer nanoparticles via a ring opening polymerization and subsequent postpolymerization modification strategies. The polymer, designed with both pH-responsive acetal linkages and a norbornene group, allows for highly efficient postpolymerization modifications through a range of chemistries to conjugate imaging agents and solubilizing arms to direct self-assembly. To demonstrate the potential of this approach, polycarbonate-based nanoparticles were tested for biocompatibility and their ability to be internalized in A549 and IMR-90 cell lines.