Value of indium-111 tropolonate autologous granulocyte scintigraphy in the assessment of inflammatory bowel disease.
Value of indium-111 tropolonate autologous granulocyte scintigraphy in the assessment of inflammatory bowel disease.
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DOI：
10.3109/00365529009093157
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发表时间：
1990
期刊：
影响因子：
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通讯作者：
G. Crama-bohbouth;A. Peña;J. Arndt;R. T. Tjon;A. Tham;H. Verspaget;I. Weterman;E. Pauwels;C. Lamers
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文献类型：
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作者：
G. Crama-bohbouth;A. Peña;J. Arndt;R. T. Tjon;A. Tham;H. Verspaget;I. Weterman;E. Pauwels;C. Lamers
铟-111自体白细胞扫描是一种非侵入性和可靠的技术，用于检测腹部脓肿。在过去的十年中，已经发表了几篇关于使用该技术评估炎症性肠病（IBD）的论文，结果各不相同。我们对莱顿大学医院的62例IBD患者进行了前瞻性研究，以评估铟-111托泊酸自体粒细胞扫描的诊断价值。51例患者患有克罗恩病（CD）（30例累及小肠，18例仅累及结肠，3例同时累及小肠和结肠），11例患有溃疡性结肠炎（UC）。26例有活动性小肠疾病证据的患者中有21例的扫描结果为真阳性（灵敏度为80%）。然而，准确评估疾病的定位和程度往往是困难的。另外5名患者的扫描结果为假阴性。7例患者的扫描结果为真阴性。无假阳性，小肠克罗恩病的诊断准确率为85%。相反，在32例结肠疾病（CD和UC）患者中，26例在定位和范围上与标准检查一致，3例假阴性（灵敏度90%），3例真阴性（诊断准确率91%）。患者对该手术的可接受性明显上级放射学和内窥镜检查。总之，这项技术在评估活动性结肠疾病的定位和程度以及禁忌使用侵入性技术的重症患者中具有明确的地位。（250字处删节）
Indium-111 autologous leucocyte scanning is a non-invasive and reliable technique for the detection of abdominal abscesses. In the past decade several papers have been published concerning the use of this technique in the assessment of inflammatory bowel disease (IBD) with variable results. We conducted a prospective study of 62 patients with IBD attending the Leiden University Hospital, to assess the diagnostic value of indium-111 tropolonate autologous granulocyte scanning. Fifty-one patients had Crohn's disease (CD) (30 with involvement of the small bowel, 18 the colon only, and 3 patients had both localizations), and 11 had ulcerative colitis (UC). Twenty-one of 26 patients with evidence of active disease of the small intestine had a true-positive scan (sensitivity, 80%). However, accurate assessment of localization and extent of disease were often difficult. The other five patients had a false-negative scan. Seven patients had a true-negative scan. No false-positive scans were found. Thus, the diagnostic accuracy for small-intestinal Crohn's disease was 85%. In contrast, of 32 patients with colonic disease (CD and UC), 26 had a true-positive scan corresponding in localization and extent with standard investigations, 3 patients had a false-negative scan (sensitivity, 90%), and 3 had a true-negative scan (diagnostic accuracy, 91%). The patients' acceptability of this procedure was definitely superior to that for radiology and endoscopy. In conclusion, this technique has a definite place in evaluating localization and extent of active colonic disease and in severely ill patients in whom invasive techniques are contraindicated.(ABSTRACT TRUNCATED AT 250 WORDS)