Frequency- and level-dependent changes in auditory brainstem responses (ABRs) in developing mice
Frequency- and level-dependent changes in auditory brainstem responses (ABRs) in developing mice
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DOI：
10.1121/1.2180533
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发表时间：
2006-04-01
影响因子：
2.4
通讯作者：
Walsh, EJ
中科院分区：
文献类型：
--
作者：
Song, L;McGee, J;Walsh, EJ
本实验研究了听性脑干反应的发展，以定量评估其对刺激频率和强度的依赖性。在P12上未观察到对>= 16 kHz的刺激的反应，然而，在P14时观察到研究中包括的反应频率的全部范围。P12的反应阈值很高，超过100 dB SPL的所有刺激测试。阈值发展的速度逐渐增加的刺激频率之间的类似2和10 kHz，最快的变化发生在频率> 10 kHz。通过P18观察到成人样阈值。反应潜伏期和峰间间期在出生后第二和第三周迅速成熟，直到P18后才达到成人样特征。相对于I波，高阶峰的延迟是渐进性和顺序性的。波I振幅发展非单调，增长在第一个24天，并稳定在成人值类似P36。波I振幅和潜伏期水平曲线的斜率显着陡峭的比成年人在新生儿期和输入输出分析的结果，以及特定频率的成熟配置文件，支持发展模式，功能最初成熟的中频范围和收益，同时，m顶端和基底方向。(c)2006年，美国声学学会。
The development of the auditory brainstem response was studied to quantitatively assess its dependence on stimulus frequency and level. Responses were not observed to stimuli >= 16 kHz on P12, however, the full range of responsive frequencies included in the study was observed by P14. Response thresholds were high on P12, exceeding 100 dB SPL for all stimuli tested. The rate of threshold development increased progressively for stimulus frequencies between similar to 2 and 10 kHz, with the most rapid changes occurring at frequencies > 10 kHz. Adultlike thresholds were observed by P18. Response latencies and interpeak intervals matured rapidly over the course of the second and third postnatal weeks and did not achieve adultlike characteristics until after P18. Latencies of higher-order peaks were progressively and sequentially delayed relative to wave I. Wave I amplitudes developed nonmonotonically, growing during the first 24 days and stabilizing at adult values by similar to P36. Slopes of wave I amplitude-and latency-level curves were significantly steeper than those of adults during the neonatal period and the outcome of input-output analyses, as well as frequency-specific maturational profiles, support developmental models in which function initially matures in the mid-frequency range and proceeds, simultaneously, m both apical and basal directions. (c) 2006 Acoustical Society of America.