Daily illumination exposure and melatonin: influence of ophthalmic dysfunction and sleep duration.
Daily illumination exposure and melatonin: influence of ophthalmic dysfunction and sleep duration.
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DOI：
10.1186/1740-3391-3-13
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发表时间：
2005-12-01
影响因子：
--
通讯作者：
Lazzaro, Douglas R
中科院分区：
文献类型：
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作者：
Jean-Louis, Girardin;Kripke, Daniel F;Lazzaro, Douglas R
背景：眼部病理学降低了光维持最佳昼夜节律的功效。我们研究了眼功能障碍是否解释了老年人褪黑激素分泌的独特差异，而日常照明，医疗和社会人口因素解释了上述差异。我们还研究了眼功能障碍是否影响环境照明和melatonin.METHODS之间的关系：30名老年人（平均年龄= 69岁;黑人= 42%和白人= 58%）的两种性别参加了这项研究。在基线时收集人口统计学和健康数据。参与者在SUNY Downstate Medical Center进行眼科检查，佩戴活动记录仪以监测照明和睡眠，并收集尿液样本以估计aMT 6s浓度。结果：分层回归分析显示，照明因素解释aMT 6s测量值的29%的方差。由眼科因素、睡眠时间和种族解释的方差比例分别为10%、2%和2%。光照因素解释了aMT 6s顶相变异的19%。由眼科因素、睡眠时间和种族解释的方差比例分别为11%、17%和2%。控制睡眠时间和种族减少照明和褪黑激素之间的相关性，而控制眼科因素没有。结论：眼科检查显示，眼内压升高和大杯盘比独立与早期褪黑激素的时间。较低的光照暴露也与早期褪黑激素时间有独立的关联。可以想象，眼科和照明因素可能对褪黑激素分泌的时间产生叠加效应，这反过来又可能使个体易于经历清晨醒来。
BACKGROUND: Ocular pathology lessens light's efficacy to maintain optimal circadian entrainment. We examined whether ophthalmic dysfunction explains unique variance in melatonin excretion of older adults over and above the variance explained by daily illumination, medical, and sociodemographic factors. We also examined whether ophthalmic dysfunction influences relationships between ambient illumination and melatonin.METHODS: Thirty older adults (mean age = 69 years; Blacks = 42% and Whites = 58%) of both genders participated in the study. Demographic and health data were collected at baseline. Participants underwent eye exams at SUNY Downstate Medical Center, wore an actigraph to monitor illumination and sleep, and collected urine specimens to estimate aMT6s concentrations.RESULTS: Hierarchical regression analysis showed that illumination factors explained 29% of the variance in aMT6s mesor. The proportion of variance explained by ophthalmic factors, sleep duration, and race was 10%, 2%, and 2%, respectively. Illumination factors explained 19% of the variance in aMT6s acrophase. The proportion of variance explained by ophthalmic factors, sleep duration, and race was 11%; 17%; and 2%, respectively. Controlling for sleep duration and race reduced the correlations between illumination and melatonin, whereas controlling for ophthalmic factors did not.CONCLUSION: Ophthalmic exams showed that elevated intraocular pressure and large cup-to-disk ratios were independently associated with earlier melatonin timing. Lower illumination exposure also had independent associations with earlier melatonin timing. Conceivably, ophthalmic and illumination factors might have an additive effect on the timing of melatonin excretion, which in turn might predispose individuals to experience early morning awakenings.