SYSTEMIC HISTOPATHOLOGY OF RATS WITH CCL4-INDUCED HEPATIC CIRRHOSIS
SYSTEMIC HISTOPATHOLOGY OF RATS WITH CCL4-INDUCED HEPATIC CIRRHOSIS
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DOI：
10.1258/002367791780808121
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发表时间：
1991-01-01
影响因子：
2.4
通讯作者：
INAGAKI, M
中科院分区：
文献类型：
--
作者：
DOI, K;KURABE, S;INAGAKI, M
对CCl_4诱导的大鼠肝硬变进行了系统的组织病理学检查。肝硬变大鼠脾适度充血，胰腺明显水肿，腺泡细胞局灶性变性，胰腺十二指肠淋巴结巨噬细胞大量出血和吞噬含铁血黄素，肺动脉和心脏右心房出现单核细胞含铁血黄素样颗粒，局灶性节段性肾小球硬化。此外，在这些动物的外周血涂片中也经常发现靶细胞数量的显著增加和少量带有含铁血黄素颗粒的单核细胞的出现。这些发现被认为对CCl4诱导的大鼠肝硬化模型的使用具有重要意义。
Systemic histopathological examinations were carried out on rats with CCl4-induced hepatic cirrhosis. Moderate congestion in the spleen, prominent oedema and focal acinar cell degeneration in the pancreas, marked haemorrhage and phagocytosis of haemosiderin by macrophages in the pancreaticoduodenal lymph node, appearance of monocytes bearing haemosiderin-like granules in the pulmonary arteries and cardiac right atrium, and focal segmental glomerulosclerosis were consistently observed in rats with hepatic cirrhosis. In addition, a marked increase in number of target cells and the appearance of a small number of monocytes bearing haemosiderin-like granules were also commonly found in the peripheral blood smears of these animals. These findings are considered to be important in the use of the CCl4-induced model of hepatic cirrhosis in the rat.