THE METABOLISM OF PHOSPHOINOSITIDE-DERIVED MESSENGER MOLECULES
THE METABOLISM OF PHOSPHOINOSITIDE-DERIVED MESSENGER MOLECULES
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DOI：
10.1126/science.3024320
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发表时间：
1986-12-19
期刊：
影响因子：
56.9
通讯作者：
WILSON, DB
中科院分区：
文献类型：
--
作者：
MAJERUS, PW;CONNOLLY, TM;WILSON, DB
磷酸肌苷是存在于所有真核细胞中的少量磷脂。它们是信使分子的储存形式，这些信使分子通过细胞膜传递信号并引起对细胞外激动剂的反应。磷酸肌苷分解释放信使分子或信使分子的前体。形成了许多不同的化合物，尽管只有少数化合物的功能是已知的。本文综述了近年来有关磷酸肌苷产物形成途径及其代谢控制因素的研究进展。
The phosphoinositides are minor phospholipids present in all eukaryotic cells. They are storage forms for messenger molecules that transmit signals across the cell membrane and evoke responses to extracellular agonists. The phosphoinositides break down to liberate messenger molecules or precursors of messenger molecules. Many different compounds are formed, although the functions of only a few are understood. Recent studies elaborating the pathways for formation of products from phosphoinositides and the factors controlling their metabolism are summarized here.