Endocrine disrupting and carcinogenic effects of decabromodiphenyl ether.
Endocrine disrupting and carcinogenic effects of decabromodiphenyl ether.
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DOI：
10.3389/fendo.2023.1183815
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发表时间：
2023
影响因子：
5.2
通讯作者：
中科院分区：
文献类型：
--
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十溴二苯醚(BDE209)是一种被广泛使用的基本工业阻燃剂，最近有报道称其在人体血清中的含量有所增加。由于BDE209和甲状腺激素的结构相似，其对甲状腺的毒性作用特别令人担忧。PubMed数据库中的原始文章使用术语“BDE209”、“十溴二苯醚”、“内分泌干扰”、“甲状腺”、“致癌”、“多溴联苯醚”、“多溴联苯醚”及其同义词收集，从开始到2022年10月。在最初确定的748项研究中，45项入选，强调了BDE209对内分泌系统的不良影响。BDE209可能不仅对甲状腺功能有毒性作用，而且可能在多个层面上对甲状腺癌的发生有影响，例如通过直接干扰TR、下丘脑-垂体-甲状腺(HPT)轴、酶活性和甲基化。然而，关于BDE209的甲状腺毒性的确切途径还不可能得出明确的结论。虽然BDE209对甲状腺的毒性作用已经被很好地研究了，但它的致癌作用仍然不清楚，还需要进一步的研究。
Decabromodiphenyl ether (BDE209), an essential industrial flame retardant that is widely used, has recently been reported to be increasing in human serum. Due to the structural similarity between BDE209 and thyroid hormones, its toxic effects on the thyroid are of particular concern. Original articles in the PubMed database were collected using the terms “BDE209”, “decabromodiphenyl ether”, “endocrine disrupting”, “thyroid”, “carcinogenesis”, “polybrominated diphenyl ethers”, “PBDEs,” and their synonyms from inception up to October of 2022. Of the 748 studies initially identified, 45 were selected, which emphasized the adverse effects of BDE209 on endocrine system. BDE209 may have a toxic effect not only on thyroid function but also on thyroid cancer tumorigenesis at multiple levels, such as by directly interfering with the TR, hypothalamic-pituitary-thyroid (HPT) axis, enzyme activity, and methylation. However, it is impossible to draw a definitive conclusion on the exact pathway of thyroid toxicity from BDE209. Although the toxic effects of BDE209 on the thyroid have been well investigated, its tumorigenic effects remain unclear and further research is necessary.
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