Bacterial colonisation of porous titanium coatings for orthopaedic implant applications - effect of surface roughness and porosity
Bacterial colonisation of porous titanium coatings for orthopaedic implant applications - effect of surface roughness and porosity
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DOI：
10.1179/0032589913z.000000000124
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发表时间：
2013-09-01
影响因子：
1.4
通讯作者：
Vleugels, J.
中科院分区：
文献类型：
--
作者：
Braem, A.;Van Mellaert, L.;Vleugels, J.
骨长入和通过多孔涂层的骨科植入物可以大大提高固定。然而，气孔的引入增加了表面粗糙度，也增加了细菌粘附的风险，这可能导致感染（在极端情况下，甚至死亡），并且由于需要进行翻修的高风险，使植入手术复杂化。因此，在不增加感染风险的情况下改善骨整合是种植学的主要挑战。在体外研究了不同粗糙度和孔隙度的钛表面上葡萄球菌的粘附和生物膜的形成。多孔纯钛涂层是通过基于电泳沉积TiH2然后在真空中热处理的PM工艺路线获得的，与最先进的真空等离子喷涂涂层相比，显著减少了表面的细菌定植。通过额外的表面修饰可以进一步减少生物膜的形成。
Bone ingrowth into and through porous coatings on orthopaedic implants can substantially improve fixation. However, the introduction of pores increases surface roughness and also the risk of bacterial adherence, which can lead to infection (in extreme cases, to death) and complicate implant surgery due to the high risk of revision being required. Improving osseointegration without increasing infection risk is therefore a major challenge in implantology. Staphylococcal adhesion and biofilm formation on Ti surfaces of varying roughness and porosity have been investigated in vitro. Porous pure titanium coatings, obtained by a PM processing route based on the electrophoretic deposition of TiH2 followed by thermal treatment in vacuum, significantly reduced bacterial colonisation of the surface compared with a state-of-the-art vacuum plasma sprayed coating. Further reduction of biofilm formation could be obtained by additional surface modification.