VITAMIN-K DEFICIENCY IN CHRONIC-ALCOHOLIC MALES
VITAMIN-K DEFICIENCY IN CHRONIC-ALCOHOLIC MALES
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DOI：
10.1111/j.1530-0277.1986.tb05167.x
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发表时间：
1986-12-01
期刊：
影响因子：
--
通讯作者：
JACOB, R
中科院分区：
文献类型：
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作者：
IBER, FL;SHAMSZAD, M;JACOB, R
Twenty male alcoholic subjects were studied initially within 1 day after stopping alcohol and again after about 1 week. Vitamin and mineral measurements were made on blood and abnormal prothrombin molecules quantitated for vitamin K status. Nine of the 20 patients received menadiol after the initial blood sample. Twelve of the alcoholics had significant elevations of abnormal prothrombin. Of these 12, all five who received vitamin K reduced the abnormal prothrombin levels toward normal but no change was observed in the seven who did not receive vitamin K. All nine patients receiving vitamin K lowered the abnormal prothrombin levels significantly whereas there was no change in those 11 who did not receive vitamin K. The prothrombin time by the one-stage technique was normal in all patients. These data suggest that the production of abnormal prothrombin is frequently present in alcoholics and this may represent a subclinical vitamin K deficiency.
