Target selection by cortical axons: alternative mechanisms to establish axonal connections in the developing brain.
Target selection by cortical axons: alternative mechanisms to establish axonal connections in the developing brain.
复制标题
皮质轴突的目标选择：在发育中的大脑中建立轴突连接的替代机制。
DOI：
10.1101/sqb.1990.055.01.045
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Terashima,T
中科院分区：
文献类型：
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作者：
O'Leary,DD;Bicknese,AR;DeCarlos,JA;Heffner,CD;Koester,SE;Kutka,LJ;Terashima,T
发育神经生物学的一个基本问题是神经元群体与其目标之间建立特定联系的机制。关于这一主题的大部分知识都来自对简单神经系统（包括脊椎动物和无脊椎动物）的体内和体外研究（Purves 和 Lichtman 1985）。这些研究得出了关于轴突发育行为的许多概括。首先，生长锥对于神经突伸长、定向寻路和目标识别至关重要（Kater 和 Guthrie，本卷）。其次，形成不同侧枝投射的神经元初级轴突的分支是通过轴突生长锥在其通路中特定点的分叉来实现的（Shaw and Bray 1971；Bray 1973；Wesssels and Nuttall 1978；Raper et al. 1983）。最后，生长锥的这些行为是响应轴突通路内编码或发育的局部分子线索而做出的（Hamburger 1988）。直到最近才意识到，发育中的轴突的主要群体并不以这种刻板的方式表现。我们在此描述我们对从大鼠新皮质第 5 层到皮质下目标的轴突投射发育的研究，以说明替代方案
A fundamental issue in developmental neurobiology is the mechanism by which specific connections are established between neuronal populations and their targets. Much of what is known about this subject has come from the study of simple neural systems, both vertebrate and invertebrate, both in vivo and in vitro (Purves and Lichtman 1985). These studies have led to a number of generalizations regarding the behavior of developing axons. First, the growth cone is essential for neurite elongation, directional pathfinding, and target recognition (Kater and Guthrie, this volume). Second, the branching of the primary axon of neurons that form divergent collateral projections is achieved by the bifurcation of the axonal growth cone at specific points in its pathway (Shaw and Bray 1971; Bray 1973; Wessells and Nuttall 1978; Raper et al. 1983). Finally, these behaviors of the growth cone are made in response to local molecular cues encoded within, or that develop within, the axonal pathway (Hamburger 1988). It has only recently been realized that major populations of developing axons do not behave in this stereotyped manner. We describe here our studies of the development of axonal projections from layer 5 of the rat neocortex to subcortical targets to illustrate alternative