Dynamic contrast-enhanced MRI of benign prostatic hyperplasia and prostatic carcinoma: correlation with angiogenesis
Dynamic contrast-enhanced MRI of benign prostatic hyperplasia and prostatic carcinoma: correlation with angiogenesis
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DOI：
10.1016/j.crad.2007.07.023
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发表时间：
2008-02-01
影响因子：
2.6
通讯作者：
Yang, Y.
中科院分区：
文献类型：
--
作者：
Ren, J.;Huan, Y.;Yang, Y.
目的：探讨动态磁共振造影（DCE MRI）对前列腺疾病的诊断和鉴别诊断价值，并探讨SI-T曲线参数与血管生成的相关性。材料与方法：对21例确诊前列腺癌（Pca）患者和29例确诊良性前列腺增生（BPH）患者进行DCE MRI检查。使用最大峰值时间、增强程度和增强率的阈值来检查分化的诊断特征。然后分析信号强度-时间曲线（SI-T曲线），并探讨SI-T曲线参数与血管内皮生长因子（VEGF）表达水平和微血管密度（MVD）的相关性。所有患者均行前列腺切除术。DCE MRI与组织学表现相关。结果：Pca表现出较强的增强，峰值时间早，增强幅度大，增强率高（p < 0.05）。在SI-T曲线类型上，BPH组A型6例，B型10例，C型13例，而Pca组A型14例，B型6例，C型1例（χ 2检验，χ 2 = 13.57, P < 0.005）。前列腺癌组织中VEGF和MVD的表达水平高于BPH组织。峰值时间与VEGF、MVD表达水平呈负相关，而增强程度和增强率呈正相关（Pearson相关，p < 0.05）。结论：基于t2加权成像，DCE MRI曲线有助于前列腺组织良恶性鉴别。在本研究中，C型曲线很少出现在恶性疾病中，但这些结果有待证实。(C) 2007年英国皇家放射学院。Elsevier Ltd.出版。版权所有。
AIM: To investigate the diagnostic and differential diagnostic values of dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) in prostatic diseases, and to investigate the correlation between the parameters of SI-T curves and angiogenesis.MATERIALS AND METHODS: Twenty-one patients with proven prostatic carcinoma (Pca) and 29 patients with proven benign prostatic hyperptasia (BPH) were examined using DCE MRI. Diagnostic characteristics for differentiation were examined using threshold values for maximum peak time, enhancement degree, and enhancement rate. Then, the signal intensity-time curves (SI-T curves) were analysed, and the correlations between the parameters of SI-T curves and the expression Levels of vascular endothelial growth factor (VEGF) and microvascular density (MVD) were investigated. All patents underwent prostatectomy. DCE MRI and histological findings were correlated.RESULTS: Pca showed stronger enhancement with an earlier peak time, higher enhancement, and enhancement rate (p < 0.05). Regarding the type of SI-T curves, in the BPH group six were type A, 10 were type B, and 13 were type C, whereas in the Pca group, 14 were type A, six were type B, and only one was type C (Chi-square test, chi(2) = 13.57, P < 0.005). The VEGF and MVD expression levels of Pca were higher than those of BPH. Peak time was negativety correlated with the expression Levels of VEGF and MVD, whereas the enhancement degree and enhancement rate showed positive correlations (Pearson correlation, p < 0.05).CONCLUSION: Based on T2-weighted imaging, DCE MRI curves can help to differentiate benign from malignant prostate tissue. In the present study the type C curve was rarely seen with malignant disease, but these results need confirmation. (C) 2007 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.