Midlife blood pressure and the risk of hippocampal atrophy - The Honolulu Asia Aging Study
Midlife blood pressure and the risk of hippocampal atrophy - The Honolulu Asia Aging Study
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DOI：
10.1161/01.hyp.0000132475.32317.bb
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发表时间：
2004-07-01
期刊：
影响因子：
8.3
通讯作者：
Launer, LJ
中科院分区：
文献类型：
--
作者：
Korf, ESC;White, LR;Launer, LJ
海马萎缩（HA）通常归因于阿尔茨海默病的神经原纤维缠结和神经炎斑块。然而，海马体易受全脑缺血的影响，这可能导致萎缩。我们调查了1900年至1919年出生的日裔美国男性样本中中年血压（BP）和晚年HA的相关性。在1965年至1971年期间测量了3次BP。在1994年至1996年，一个子样本接受了大脑的磁共振成像（MRI）。通过在相关扫描切片上手动绘制感兴趣区域来估计海马体积; HA定义为海马体积的最低四分位数。MRI还评估了皮质和皮质下梗死、腔隙和白色高信号。估计HA与收缩压（≥ 140 mm Hg）和舒张压（
Hippocampal atrophy ( HA) is usually attributed to the neurofibrillary tangles and neuritic plaques of Alzheimer disease. However, the hippocampus is vulnerable to global ischemia, which may lead to atrophy. We investigated the association of midlife blood pressure (BP) and late-life HA in a sample of Japanese-American men born between 1900 and 1919. BP was measured on 3 occasions between 1965 and 1971. In 1994 to 1996 a subsample underwent magnetic resonance imaging (MRI) of the brain. Hippocampal volume was estimated by manually drawing regions of interest on relevant scan slices; HA was defined as the lowest quartile of hippocampal volume. Also assessed on the MRI were cortical and subcortical infarcts, lacunes, and white matter hyperintensities. The risk ( OR, 95% CI) was estimated for HA associated with systolic (= 140 mm Hg) and diastolic (