Normal serum response to oral beta-carotene in humans.
Normal serum response to oral beta-carotene in humans.
复制标题
人类对口服 β-胡萝卜素的正常血清反应。
DOI：
10.1080/07315724.1989.10720337
复制
发表时间：
1989
影响因子：
3.5
通讯作者：
Sugerman,S
中科院分区：
文献类型：
--
作者：
Henderson,CT;Mobarhan,S;Bowen,P;Stacewicz-Sapuntzakis,M;Langenberg,P;Kiani,R;Lucchesi,D;Sugerman,S
本研究旨在确定（1）对单次口服剂量β-胡萝卜素（BC）的正常血清反应，（2）进餐时间和对膳食脂质的血清反应对血清BC的影响，（3）给予BC对其他血清类胡萝卜素和类维生素A的影响，以及（4）身体组成与血清BC反应的关系。受试者服用一剂BC，含500 kcal无BC液体饮食;空腹和每小时采集静脉血8小时，并在24小时再次采集。在给药后4小时食用第二份不含BC的液体餐;一些受试者省略了该午餐。血清BC水平升高，最初在5小时达到峰值，但在大多数受试者中继续被吸收，与基线值相比，在24小时保持显著升高（p <0.001），与BC剂量无关。BC吸收曲线下面积（8小时AUC）随BC剂量线性增加，并与餐后血清甘油三酯（TG）峰值呈正相关（n = 26次试验，r = 0.56，p <0.003）。省略午餐显著延迟了最初的BC峰值至7小时（p <0.0004）。血清中的视黄醇、α-胡萝卜素、隐黄质、番茄红素和叶黄素水平保持不变。血清视黄酯没有上升，在所有受试者的BC摄入后，当它上升，视黄酯上升，并与BC同时达到峰值，但在8小时内下降。初始血清BC、峰值BC、24小时BC、8小时AUC或峰值血清TG与体脂百分比之间无相关性。我们的结论是：（1）口服BC的血清反应时间与剂量无关，（2）血清BC反应在对膳食脂质有更大血清甘油三酯反应的人中更大，（3）给予剂量的BC不会改变其他血清类胡萝卜素的水平，（4）测量的血清BC参数与肥胖之间没有相关性。
This study was performed to determine (1) the normal serum response to a single oral dose of beta-carotene (BC), (2) the effect of meal timing and serum response to meal lipids on serum BC, (3) the effect of administered BC on other serum carotenoids and retinoids, and (4) the relationship of body composition to serum BC response. Subjects consumed one BC dose with a liquid 500 kcal BC-free diet; fasting and hourly venous blood was collected for 8 hours and again at 24 hours. A second liquid BC-free meal was consumed 4 hours post-dosing; this midday meal was omitted in some subjects. Serum BC levels rose and peaked initially at 5 hours, but continued to be absorbed in most subjects, remaining significantly elevated at 24 hours as compared to baseline values (p less than 0.001), independent of BC dose. The area under the BC absorption curve (8-hr AUC) increased linearly with BC dose and correlated positively with peak serum triglycerides (TG) after a meal (n = 26 tests, r = 0.56, p less than 0.003). Omission of the midday meal significantly delayed the initial BC peak to 7 hours (p less than 0.0004). Serum levels of retinol, alpha-carotene, cryptoxanthin, lycopene, and lutein remained unchanged. Serum retinyl esters did not rise in all subjects following BC intake; when it did, retinyl esters rose and peaked concomitantly with BC, but declined within 8 hours. There was no correlation between the initial serum BC, peak BC, 24-hr BC, 8-hr AUC, or peak serum TG and the percentage of body fat. We conclude that: (1) the timing of the serum response to oral BC is independent of dose, (2) the serum BC response is greater in those with a greater serum triglyceride response to meal lipids, (3) BC at the doses given does not alter the levels of other serum carotenoids, and (4) there is no correlation between the serum BC parameters measured and adiposity.