Effectiveness of the current and prior influenza vaccinations in Northern Spain, 2018-2019
Effectiveness of the current and prior influenza vaccinations in Northern Spain, 2018-2019
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DOI：
10.1016/j.vaccine.2020.01.028
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发表时间：
2020-02-18
期刊：
影响因子：
5.5
通讯作者：
Martinez-Baz, Ivan
中科院分区：
文献类型：
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作者：
Castilla, Jesus;Eugenia Portillo, Maria;Martinez-Baz, Ivan
背景资料：接种流感疫苗的目标人群可以在连续的季节重复接种疫苗，并且在前一个季节接种的疫苗可以保留预防效果。本研究旨在评估2018-2019年流感季和前一季接种灭活流感疫苗的有效性。方法：对西班牙纳瓦拉定点全科医生或医院收治的流感样疾病患者进行流感检测。从疫苗接种登记处获得当前和前三个季节的疫苗接种状态。结果：共检测甲型H1N1流感pdm 09病例381例，甲型H3 N2流感病例341例，对照1222例。与当前和前三个季节未接种疫苗的个体相比，当前季节疫苗接种对A（H1N1）pdm 09的流感疫苗有效性为57%（95%置信区间ICI]：40%，70%），无论先前剂量如何，在前一个季节接种但在当前季节未接种的流感疫苗有效性为48%（95%CI：14%，68%）。这些估计值分别为12%（95%CI：-23%，37%）和27%（95%CI：-22%，56%），针对甲型H3 N2流感。自2009年以来接种流感疫苗中两种A（H1N1）pdm 09毒株A/Michigan/45/2015和A/加州/07/2009的个体具有更高的保护性（68%; 95%CI：53%，77%）比仅接种A/Michigan/45/2015疫苗的受试者高（29%，p = 0.020）或仅A/加州/07/2009（34%，p = 0.005）。这些结果表明，2018年流感疫苗接种对A（H1N1）pdm 09的有效性中等，对A（H3 N2）流感的有效性较低。2019赛季。前几个季节的疫苗接种保持了显著的保护效果。以前的疫苗中包含的菌株与当前的疫苗菌株一样有效，并且都增加了它们对甲型H1N1流感pdm 09的效果。(C)2020爱思唯尔有限公司版权所有。
Background: The population targeted for influenza vaccination can be repeatedly vaccinated over successive seasons, and vaccines received in previous seasons may retain preventive effect. This study aims to estimate the effectiveness of inactivated influenza vaccines received in the current and prior seasons in the 2018-2019 season.Methods: Influenza-like illness patients attended by sentinel general practitioners or admitted to hospitals in Navarre, Spain, were tested for influenza. Vaccination status in the current and three prior seasons was obtained from the vaccination registry. The test-negative design was used to estimate the vaccine effectiveness.Results: A total of 381 influenza A(H1N1)pdm09 cases, 341 A(H3N2) cases and 1222 controls were analysed. As compared to individuals unvaccinated in the current and three prior seasons, the influenza vaccine effectiveness against A(H1N1)pdm09 was 57% (95% confidence interval ICI]: 40%, 70%) for current season vaccination regardless of prior doses and 48% (95%Cl: 14%, 68%) for vaccination in prior seasons but not in the current season. These estimates were 12% (95%CI: -23%, 37%) and 27% (95%CI: -22%, 56%), respectively, against influenza A(H3N2). Individuals vaccinated with the two A(H1N1)pdm09 strains in influenza vaccines since 2009, A/Michigan/45/2015 and A/California/07/2009, had higher protection (68%; 95%CI: 53%, 77%) than those vaccinated with A/Michigan/45/2015 only (29%, p = 0.020) or with A/California/07/2009 only (34%, p = 0.005).Conclusion: These results suggest moderate effectiveness of influenza vaccination against A(H1N1) pdm09 and low effectiveness against A(H3N2) influenza in the 2018-2019 season. Vaccination in prior seasons maintained a notable protective effect. Strains included in previous vaccines were as effective as the current vaccine strain, and both added their effects against influenza A(H1N1)pdm09. (C) 2020 Elsevier Ltd. All rights reserved.