Cell-Type Specific Messenger Functions of Extracellular Calcium in the Anterior Pituitary.
Cell-Type Specific Messenger Functions of Extracellular Calcium in the Anterior Pituitary.
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DOI：
10.1210/endo.143.2.8637
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发表时间：
2002-02
期刊：
影响因子：
4.8
通讯作者：
D. Živadinović;M. Tomić;Davy Yuan;S. Stojilkovic
中科院分区：
文献类型：
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作者：
D. Živadinović;M. Tomić;Davy Yuan;S. Stojilkovic
Calcium can serve not only as an intracellular messenger, but also as an extracellular messenger controlling the gating properties of plasma membrane channels and acting as an agonist for G protein-coupled Ca2+-sensing receptors. Here we studied the potential extracellular messenger functions of this ion in anterior pituitary cells. Depletion and repletion of the extracellular Ca2+ concentration ([Ca2+]e) induced transient elevations in the intracellular Ca2+ concentration ([Ca2+]i), and elevations in [Ca2+]e above physiological levels decreased [Ca2+]i in somatotrophs and lactotrophs, but not in gonadotrophs. The amplitudes and duration of [Ca2+]i responses depended on the [Ca2+]e and its rate of change, which resulted exclusively from modulation of spontaneous voltage-gated Ca2+ influx. Changes in [Ca2+]e also affected GH and PRL secretion. The PRL secretory profiles paralleled the [Ca2+]i profiles in lactotrophs, whereas GH secretion was also stimulated by [Ca2+]e independently of the status of voltage...
