Magnesium-mediated benzothiazole activation: a room-temperature cascade of C-H deprotonation, C-C coupling, ring-opening, and nucleophilic addition reactions.
Magnesium-mediated benzothiazole activation: a room-temperature cascade of C-H deprotonation, C-C coupling, ring-opening, and nucleophilic addition reactions.
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DOI：
10.1002/anie.201103275
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发表时间：
2011-10
影响因子：
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通讯作者：
V. Blair;W. Clegg;A. Kennedy;Zoe Livingstone;Luca Russo;Eva Hevia
中科院分区：
文献类型：
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作者：
V. Blair;W. Clegg;A. Kennedy;Zoe Livingstone;Luca Russo;Eva Hevia
配体结构域(o)化：与使用格氏试剂直接脱质子苯并噻唑相反，用1处理苯并噻唑会导致一种新型的活化。最初的镁化引发了一个不可阻挡的多米诺骨牌反应：C-C偶联、开环、亲核加成和脱质子生成2。四氢呋喃(四氢呋喃。
Ligand domin(o)ated: In contrast to the straightforward deprotonation of benzothiazole using Grignard reagents, treatment of benzothiazole with 1 leads to a novel type of activation. The initial magnesiation initiates an unstoppable domino reaction of C-C coupling, ring opening, nucleophilic addition, and deprotonation to give 2. THF=tetrahydrofuran.