Nighttime sleep duration, 24-hour sleep duration and risk of all-cause mortality among adults: a meta-analysis of prospective cohort studies.
Nighttime sleep duration, 24-hour sleep duration and risk of all-cause mortality among adults: a meta-analysis of prospective cohort studies.
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DOI：
10.1038/srep21480
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发表时间：
2016-02-22
影响因子：
4.6
通讯作者：
Zhang D
中科院分区：
文献类型：
--
作者：
Shen X;Wu Y;Zhang D
我们进行了一项剂量-反应荟萃分析，以总结前瞻性队列研究中关于夜间睡眠时间和24小时睡眠时间与成人全因死亡率风险之间关系的证据。相关研究通过检索Embase和PubMed数据库确定至2015年3月。采用两阶段随机效应剂量反应荟萃分析，结合研究特异性相对风险和95%置信区间[rr (95% ci)]。共纳入35篇文章。与7小时/天相比，4、5、6、8、9、10和11小时/天夜间睡眠的全因死亡率的RRs （95% ci）分别为1.07（1.03-1.13）、1.04（1.01 - 1.07）、1.01（1.00-1.02）、1.07（1.06-1.09）、1.21（1.18-1.24）、1.37（1.32-1.42）和1.55(1.47-1.63)（1526,609名参与者中有146,830例死亡），4、5、6、8、9的风险分别为1.09（1.04 - 1.14）、1.05（1.02 - 1.09）、1.02（1.00-1.03）、1.08（1.05 - 1.10）、1.27（1.20-1.36）、1.53（1.38-1.70）和1.84（1.59-2.13）。分别为每天10小时和11小时的24小时睡眠（903,727名参与者中有101,641例死亡）。上述关系在基线时无心血管疾病和癌症的受试者中也存在，其他协变量对这种关系没有实质性影响。结果表明，建议每天7小时的睡眠时间以防止成年人过早死亡。
A dose-response meta-analysis was conducted to summarize evidence from prospective cohort studies about the association of nighttime sleep duration and 24-hour sleep duration with risk of all-cause mortality among adults. Pertinent studies were identified by a search of Embase and PubMed databases to March 2015. A two-stage random-effects dose–response meta-analysis was used to combine study-specific relative risks and 95% confidence intervals [RRs (95% CIs)]. Thirty-five articles were included. Compared with 7 hours/day, the RRs (95% CIs) of all-cause mortality were 1.07 (1.03–1.13), 1.04 (1.01–1.07), 1.01 (1.00–1.02), 1.07 (1.06–1.09), 1.21 (1.18–1.24), 1.37 (1.32–1.42) and 1.55 (1.47–1.63) for 4, 5, 6, 8, 9, 10 and 11 hours/day of nighttime sleep, respectively (146,830 death cases among 1,526,609 participants), and the risks were 1.09 (1.04–1.14), 1.05 (1.02–1.09), 1.02 (1.00–1.03), 1.08 (1.05–1.10), 1.27 (1.20–1.36), 1.53 (1.38–1.70) and 1.84 (1.59–2.13) for 4, 5, 6, 8, 9, 10 and 11 hours/day of 24-hour sleep, respectively (101,641 death cases among 903,727 participants). The above relationships were also found in subjects without cardiovascular diseases and cancer at baseline, and other covariates did not influence the relationships substantially. The results suggested that 7 hours/day of sleep duration should be recommended to prevent premature death among adults.